She explains what senescent cells actually do, how the signals they release can spread damage from one tissue to another, and why calling them “zombie cells” does not come close to telling the full story. We talk about the possibility of intervening before cells reach an irreversible state, why targeting the biology of ageing itself may matter more than tackling diseases one at a time, and what meaningful rejuvenation should really look like.

Prof Lorna also discusses the challenge of turning lab science into therapies through her spin-out SENISCA, her work with L’Oréal, and why conditions such as IPF are an important place to begin. Along the way, she addresses the tougher questions too, including how longevity science moves from promise to treatment, where the field risks drifting into hype, and whether these advances will be available to the many or only the few.

Links:

http://www.senisca/

http://www.iscarna.com/

https://teamrna.wixsite.com/harrieslab

https://experts.exeter.ac.uk/1873-lorna-harries

Innovate UK ICURe Programme

https://iuk-business-connect.org.uk/programme/icure/

00:00 Podcast Intro Guest Setup

01:50 Meet Professor Harris Basics

02:16 DNA RNA Explained

03:38 RNA Splicing And Ageing

05:48 What Senescent Cells Do

07:38 Reversing Senescence Window

09:01 Fat Tissue And Faster Ageing

11:01 Splicing As Central Hallmark

12:11 Rejuvenation Discovery Story

13:52 From Lab To Spinout Company

16:41 Translating Science To Products

19:17 Therapy Targets IPF And Beyond

21:45 Why Translation Often Fails

23:19 Defining Real Rejuvenation

25:14 Avoiding Hype In Longevity

27:17 Who Is Lagging Behind

27:37 Regulatory Mindset Shift

28:47 Trials Built for Ageing

29:28 Scepticism and Overhype

31:25 Is Ageing a Disease

32:49 Policy and Demographic Timebomb

33:48 Advocacy and Communication

35:24 Personal Ageing Habits

36:24 Key Unasked Questions

39:15 Longevity for the Rich

41:43 Access via NHS and Patents

45:06 Rapid Fire and Myths

49:05 Closing Reflections

Marc explains Retia’s aim to detect early deterioration, guide diagnosis and therapy, and avoid the unreliability, invasiveness and complexity of older tools, noting deployment in 75 US hospitals and distribution via Medtronic, plus presence in 18 countries.

He highlights FDA clearance for Argos Infinity enterprise software, which extends insights across the hospital and to clinicians’ phones and laptops, and shares a case where rapid detection of falling stroke volume revealed bleeding during AAA repair. The conversation covers workflow-first design, interoperability, cybersecurity, regulatory strategy, and a future path from ICU to broader wards and ultimately wearables for earlier intervention and preventative care.

00:00 Beyond Longevity Intro

00:44 Meet Mark Zeel

01:40 Rata Medical Mission

02:54 Argos Infinity Launch

03:58 Clinicians Want Real Time

05:19 Surgery Near Miss Story

07:20 Why Accuracy Matters

08:42 Why Algorithms Are Hard

10:08 From ICU To Wearables

12:20 Scaling Distribution Globally

13:22 Plug And Play Integration

15:22 Wearables And Data Overload

18:31 Alerts And Clinical Judgment

20:16 AI As Decision Support

21:56 US Versus Europe Markets

23:09 Wearables Beyond EMRs

23:57 Regulation And Cybersecurity

25:07 FDA And AI Pathways

26:50 Clinician Workflow Design

29:39 Bad Data From Friction

31:58 Open Ecosystems Future

33:25 Prevention And Longevity

35:46 Personal Why Wearables Matter

39:24 From ICU To Early Detection

41:44 Rapid Fire And Wrap

In this episode, Avivah and Daphna explore how longer lives are reshaping work, business, and society. Avivah argues that longevity is not just a health story but a structural shift that is forcing organisations to rethink how they are built, how careers unfold, and how different generations work together.

She explains why the old pyramid model of the workforce is giving way to a more square demographic reality, with far more balance between younger and older generations than most institutions were designed for. That shift brings real pressure, from pensions to healthcare, but also major opportunities for businesses willing to adapt.

The conversation looks at why older workers are still too often overlooked, what businesses lose when they fail to value experience, and why age-inclusive thinking is becoming a strategic advantage rather than a social add-on. More broadly, the episode challenges outdated assumptions about ageing and asks what it would mean to build a society that treats longer lives as a source of possibility, not decline.

This episode is a reminder that longevity is not only changing how long we live, but how we work, lead, learn, and contribute across the course of our lives.

https://www.avivahwittenbergcox.com/

https://elderberries.substack.com

https://elderberries.substack.com/podcast

https://www.ted.com/search?q=Avivah+Wittenberg+Cox

https://20-first.com/

https://www.forbes.com/sites/avivahwittenbergcox/#61c5a38ebf19

00:00 Longevity Meets Work

02:06 Longevity Mega Trend

03:09 Institutions Lag Behind

05:37 From Gender To Age

07:39 Women And Longer Lives

10:08 Multi Stage Careers

11:26 Rethinking Education Midlife

15:29 Rebranding Old Age

17:54 Opportunity And Ageism

21:24 Fear Of Ageing And Happiness

25:37 Goldman Sachs And AI

27:17 Company First Mover Advantage

28:43 Who Is Leading The Way

29:52 Brands Embrace Pro Ageing

30:21 Longevity In Hospitality

31:12 Retirees As Consultants

31:56 Why Leaders Miss Demographics

35:29 Government Levers And Limits

38:34 The Square Society Shift

40:43 Measuring Longevity Readiness

43:25 Advice Four Quarter Lives

47:54 Designing A Four Quarter Life

53:22 Ageing Better Than Expected

54:46 Rapid Fire And Wrap Up

https://www.jinfiniti.com/

https://www.youtube.com/@ProfJinShe

In this episode:

00:00 Welcome and Guest Intro

01:47 From Genomics to Longevity

04:18 T1D TEDDY Study Breakthroughs

06:07 Leaving Academia for Impact

07:37 Healthspan Over Lifespan

10:09 TAO Test Act Optimise

13:20 Choosing Actionable Biomarkers

17:02 Why NAD Tops the List

21:45 NAD Decline and Key Drivers

25:21 Raising NAD Lifestyle vs Supplements

27:51 Athletes' Inflammation and Low NAD

31:54 Optimal NAD Range and Niacin Risks

37:28 SubQ Injections vs Oral NMN Data

41:42 Dosing and Cutting Useless Supplements

43:52 Access Economics and Policy Ideas

46:50 Industry Adoption and Big Names

47:59 Supplement Market Problems

50:17 Rapid Fire and Closing Takeaways

52:04 Final Summary and Goodbye

Dr Stambler shares how the ILA has grown into a global network connecting 76 nonprofits across 66 countries, organising international conferences, and running the annual Longevity Day (1st October) and Longevity Month (October) campaigns. He points to concrete wins, including efforts to support the inclusion of ageing-related conditions in the ICD and the WHO's work programme.

The conversation gets honest about the real barriers to progress. Dr Stambler argues the problem isn't convincing governments that ageing matters, it's getting them to treat it with urgency. Despite ageing representing one of the largest disease burdens globally, it remains chronically underfunded and deprioritised, in part because the research timelines required don't fit neatly into political cycles.

He also reflects on the deeper intellectual questions underpinning the field: how to balance holism and reductionism, why historical perspective is essential for longevity researchers, and how the same patterns of enthusiasm, scepticism, and neglect have repeated across centuries of rejuvenation science.

Looking ahead to 2030, Dr Stambler highlights the need for better public education, evidence-based criteria for evaluating interventions, and growing grassroots motivation, because ultimately, he believes, a longer and healthier life begins with wanting one.

In This Episode:

1. How the ILA operates across 66 countries and what it's achieved
2. Why governments acknowledge ageing but still fail to act on it
3. The long funding timelines longevity research demands — and why that's a political problem
4. Which countries are currently leading on longevity policy
5. Why solo science isn't enough and advocacy changes outcomes
6. The "Death Valley of ideas" and how to get research across it
7. Balancing holism and reductionism in longevity science
8. Why the history of rejuvenation science keeps repeating itself
9. What meaningful success in this field actually looks like.

Ilia Stambler, PhD

Chairman and CSO. Vetek (Seniority) Association – The Movement for Longevity and Quality of Life, Israel http://www.longevityisrael.org/

Chairman. International Longevity Alliance (ILA) http://www.longevityalliance.org/

Fellow. Department of Science, Technology and Society, Bar-Ilan University, Israel https://sts.biu.ac.il/

Author. A History of Life-Extensionism in the Twentieth Century; Longevity Promotion: Multidisciplinary Perspectives; Healthy Longevity: Policies and Practices http://longevityhistory.com

https://www.longevityhistory.com/about-the-author/

00:00 Welcome and Guest Intro

01:28 Staler Background and Mission

03:18 What the ILA Does

04:04 Key Wins and Campaigns

05:25 Public Misconceptions

07:27 Getting Governments to Act

09:14 Funding Research Long Term

10:49 Education and Conferences

12:05 Which Countries Lead

15:22 Why Advocacy Beats Solo Science

17:38 Advocacy Success Stories

20:48 Breaking Longevity Silos

21:23 Holism vs Reductionism

22:28 Why History Matters

24:17 Death Valley of Ideas

25:49 Rejuvenation Patterns Repeat

27:42 Misunderstood Longevity History

29:22 Balance and Modesty

31:23 Measuring Real Success

34:59 Making Longevity Policy

36:09 Rapid Fire Takeaways

38:58 Final Wrap Up

With a background in computer science and a lifelong passion for health optimisation, Elio offers a grounded, honest perspective on what AI in longevity medicine can do today, and where the limits still lie.

______________

What We Cover

• How LongevAI was founded and what problem it solves for longevity clinics

• What it means to automate clinical documentation without removing the clinician from the process

• How AI interprets biomarker data, and why speed and accuracy both play a role

• The hallucination problem: what it is, why it happens, and how it is being managed

• Data privacy, GDPR compliance, and anonymisation in clinical AI tools

• The importance of human oversight, why the clinician must always approve before anything reaches the client

• How AI and clinicians can learn from each other in a feedback loop

• Wearable integration and the role of continuous vs snapshot data

• Where AI in longevity is heading in two to five years, including gene therapy modelling and whole-cell simulation

• Why younger people are beginning to engage with longevity, and what still holds them back

About the Guest

Elio is the co-founder of LongevAI, a software platform built for longevity clinics. He holds a double bachelor's degree in Computer Science and Information Science, and has been focused on health optimisation and AI since his teens. He co-founded LongevAI in December 2024 alongside Cosmina Druica, whom he met through a longevity meetup community in the Netherlands.

🔗 longevai.com

Enjoyed this episode? Please subscribe, leave a review on Apple Podcasts or Spotify, and share with anyone curious about the future of longevity medicine.

Beyond Longevity is hosted by Daphna Stern · beyond-longevity.co.uk

In this episode:

00:00 Welcome and Guest Intro

01:52 Elio Background and Origins

04:01 What Lev AI Does

05:06 Automating Clinic Workflows

07:52 Speed vs Accuracy

11:45 Oversight and Patient Trust

12:57 Privacy and GDPR Security

13:56 How the Model Improves

15:06 Limits Data and Hallucinations

21:37 Training and Integrations

23:45 Personal Biomarker Walkthrough

28:34 Explaining LLMs to non-tech people

33:38 Future of AI and Longevity

35:32 Young People and Longevity

39:56 Rapid Fire Questions

43:45 Wrap Up and Key Takeaways

This episode cuts through the certainty. We talk about biomarkers and biological age, why many measurements may be tracking effects rather than causes, we discuss extracellular vesicles and the surprising limit of science. Dr Bradley discusses some of his papers and related research, and our conversation challenges much of the conventional wisdom in the longevity space.

What we cover:

-Why we still do not know what fundamentally causes ageing — and why every “root cause” often leads to something deeper

-What biomarkers really measure, what they can and cannot tell you, and which markers are most worth tracking right now

-Biological age vs chronological age: where the concept is useful, and where it gets overclaimed

-Why muscle is one of the most underrated “health organs” in ageing — and what it supports beyond strength

-Exercise for longevity: the evidence-based basics, plus what matters most for consistency and adherence

-“It is not too late”: what studies in very old adults suggest about strength gains later in life

-Extracellular vesicles: the hidden communication system between cells, and why it is getting so much attention

-Wearables: why they can still be useful even when the numbers are not perfectly accurate

This is a fascinating episode with someone who knows how to communicate science and make it relatable

Links to Dr Bradley Elliot:

- https://www.westminster.ac.uk/about-us/our-people/directory/elliott-bradley

- https://bsra.org.uk/bradley-elliott-2/

- https://www.bradelliott.online/

Papers & Research Referenced

• Perri et al. (2025) — Delphi review identifying 14 biomarkers of ageing for use in human research (co-authored by Dr Elliott)

' https://pubmed.ncbi.nlm.nih.gov/39708300/

• Lady V Barrios-Silva et al. — Activin subfamily peptides and prediction of age and physical function (undergraduate-led research, University of Westminster)

https://pubmed.ncbi.nlm.nih.gov/30178598/

• Dr Yvoni Kyriakidou (PhD) — Exercise-induced muscle damage in young and old men; extracellular vesicle characterisation post-exercise

https://pubmed.ncbi.nlm.nih.gov/34650440/

• Dr Niharika Duggal (University of Birmingham) — Masters athletes and immune function; older athletes vs. age-matched non-athletes

https://pubmed.ncbi.nlm.nih.gov/29517845/

• Stephen Harridge (King's College London) — Resistance training in 90+ year olds; gains in muscle strength and mass in the oldest old

https://pubmed.ncbi.nlm.nih.gov/10398199/

• Science paper on genetic contribution to longevity — updated estimate shifting genetic contribution to ~50% (noted with editorial by Dr Elliott)

https://www.science.org/doi/10.1126/science.adz1187

https://theconversation.com/what-new-twins-study-reveals-about-genes-environment-and-longevity-274763

https://www.ukbiobank.ac.uk/

If you enjoyed this episode, we'd love it if you took 60 seconds to leave us a review on Apple Podcasts or Spotify. It genuinely helps more people find the show and means we can keep bringing you honest, science-backed conversations like this one. Thank you

https://beyond-longevity.co.uk/

Chapters:

00:00 Why We Age

01:52 Meet Bradley Elliot

03:07 From Sports Science

05:32 Defining Ageing

07:03 Mechanisms And Theories

09:29 Biomarkers Explained

13:02 Delphi Biomarker List

16:59 Myostatin Study Story

21:25 Actionable Biomarkers

26:07 Wearables And Accuracy

27:38 Endocrine Fingerprints

30:11 Muscle And Healthy Ageing

33:21 Athletes And Immunity

34:26 Muscle Mass And Healthspan

36:36 Exercise Dose Guidelines

39:42 Resistance Training Plateau

40:42 Lifestyle Versus Genetics

42:42 Muscle Damage Study

44:44 Extracellular Vesicles Explained

46:49 Young Blood Controversy

50:08 Dream Research With Omics

56:55 What People Misjudge

58:43 It’s Never Too Late

01:02:41 Rapid Fire And Wrap

01:04:31 Final Takeaways

The central theme is a shift now reshaping aesthetic medicine: moving away from surface-level fixes and toward addressing the underlying drivers of visible ageing. A key driver, Dr Brendan explains, is inflammaging, a chronic, low-grade inflammation that builds over time and accelerates both skin ageing and broader physiological decline.

He breaks down why some conventional aesthetic approaches can backfire, particularly repeated high-heat energy treatments, which may contribute to fibrosis, uneven pigmentation, and a dull, “waxy” skin texture over time. His approach favours smarter, gentler interventions, including an anti-inflammatory 1064nm Nd:YAG laser, targeted resurfacing that can be safer across a wider range of skin types, and calming injectables such as Meso-Wharton (a peptide product derived from Wharton’s jelly) used in practice to support skin quality, texture and fine lines.

But this is not just a conversation about devices and injectables. Dr Brendan argues that better results start with better assessment and the need to factor in gut health, supplement use, stress load, and cortisol patterns before reaching for a needle or a laser. He is also candid about timelines: collagen remodelling takes time, and unrealistic expectations are one of the biggest problems in aesthetics.

For day-to-day longevity habits that support skin health, he highlights fundamentals that are often overlooked: exercise, stress management, avoiding very hot showers, and finding a retinoid your skin can consistently tolerate.

Dr Brendan Khong | London's Most Sought-after Aesthetic Doctor

Dr Brendan Khong (@drbrendankhong) • Instagram profile

00:00 Welcome and Guest Intro

02:06 Brandon’s Medical Journey

03:36 Skin as an Inflammation Mirror

07:19 Supplements and Gut Health

10:15 Overtreatment and Inflammaging

14:47 Anti-Inflammatory Laser Approach

17:39 Regenerative Injectables Peptides

21:36 Personalised Protocols and Expectations

25:18 Why Glanine Stands Out

25:57 Microspheres Not Clumps

26:55 Anti-Inflammatory Collagen

27:47 Safety Profile Focus

28:45 Building Patient Protocols

30:25 Longevity Over Quick Fixes

32:17 Future Of Aesthetics

33:41 Gentler Treatment Philosophy

34:49 Quantum Magnetic Resonance

36:18 Healthy Beauty Trends

37:25 Daily Longevity Skin Tips

40:10 Rapid Fire Longevity Qs

45:14 Final Takeaways And Wrap

Most pension systems were built around an ~80-year life expectancy. Much of today’s financial advice still follows a linear life-stage model. And many businesses have not yet reckoned with the fact that both their customers and their workforce are ageing in ways that will reshape everything.

In this episode of Beyond Longevity, I am joined by Nadine Esposito, founder of Wellthspan Advisory and a senior risk management professional, to unpack why longer lifespans are not just a medical story — they are a planning and financial one, with major implications for strategy and society.

Nadine’s path into longevity came not through medicine, but through risk, ESG, and a deep interest in the health–wealth connection. She introduces the concept of wealthspan planning: moving away from rigid life stages towards a model that accounts for career pivots, caregiving gaps, health shocks and the very real risk of outliving your money and any affordable care options.

We cover

1. The health–wealth connection — why “health is wealth” works both ways and how financial stress and poor health reinforce each other over a longer life
2. What businesses need to wake up to — ageing customer bases are changing consumption patterns across housing, travel, mobility and services
3. The workforce challenge — flexibility, lifelong learning, the rise of the “sandwich generation,” and why simply raising retirement age misses the point
4. Risk in longevity startups — data security, AI-driven health apps, sensitive personal data, and income regulations (including EU AI Act transparency obligations around human–AI interaction)
5. Longevity and inequality — why longer lives may widen the gap without smarte intervention and access

Key takeaways

1. Wealthspan planning replaces linear life-stage models with something far more dynamic and realistic
2. The two-way link between health and finances means you cannot plan one without the other
3. Businesses should start with a longevity maturity and gap assessment — and test whether products and services actually work for older customers
4. Investors should ask harder questions about IT security, regulatory readiness and risk management — not only financial fundamentals
5. Health and financial literacy, prevention, and employer/insurer incentives are among the highest-leverage policy priorities

Links

1. LinkedIn (Nadine): https://www.linkedin.com/in/nadine-esposito-b1804415/
2. Wellthspan Advisory (LinkedIn): https://www.linkedin.com/company/wellthspan-advisory
3. Website: https://www.wellthspanadvisory.com/
4. Longevity Readiness Diagnostic Tool: https://www.longevityreadinessdiagnostic.com/
5. Instagram: https://www.instagram.com/nadine.esposito_/

Beyond Longevity is hosted by Daphna. New episodes every Monday. Subscribe and listen at https://beyond-longevity.co.uk/listen

Timestamps

00:00 Welcome to Beyond Longevity + Why Longer Lives Change Money

01:40 Nadine’s Path: From Risk & ESG to the Longevity Space

03:45 From Biohacking Curiosity to the Pension Reality Check

06:42 Wealthspan Planning: Where Health and Wealth Collide

08:42 De-Risking Longevity: Individuals, Employers, and Startups

11:25 Health Data & Cybersecurity Risks in Longevity Tech

17:54 AI in Health: What Users Should Know Before Sharing Data

21:17 Investor Checklist: Security, Regulation, and Risk Appetite

26:08 Longevity’s Business Impact: Aging Customers, Products, and Cities

30:04 Mobility, Social Connection & the Rising Cost of Aging

30:57 New “Life Events” After Retirement: Property, Divorce & Starting Businesses

32:45 The Aging Workforce: Lifelong Learning, Flex Work & Employee Resilience

34:22 Rethinking Retirement Age: Reskilling, Career Resets & Hiring Barriers

39:25 What Policy Should Change First? Financial + Health Literacy & Prevention

45:26 Will Longevity Widen Inequality? When Wealth Becomes Health

46:50 Personal Playbook: Healthspan Over Lifespan & Building Sustainable Habits

49:03 How Any Business Can Prepare: Longevity Maturity Checks & Accessibility

51:48 Key Takeaways + Rapid-Fire Q&A (Sleep, News, Fasting Myth)

58:09 Final Wrap: Longevity Is a Planning Topic (Money, Work, Risk)

In this episode of Beyond Longevity, we sit down with Professor David Weinkove: Chair of the British Society for Research on Ageing (BSRA), Professor at Durham University, and Co-founder and CSO of Magnitude Biosciences. David's lab uses the short-lived nematode C. elegans to run fast, rigorous experiments looking for interventions that extend healthspan and lifespan, and the results are pointing in some surprising directions.

We cover how Prof David moved from physics into experimental molecular biology, how his team discovered that bacterial strains and metabolites can dramatically alter how long worms stay active, and what inhibiting bacterial folate synthesis reveals about the biology of ageing. He also explains how worm movement is a practical proxy for healthspan and why that matters for scaling up research.

The conversation gets into the thornier questions, too: when do you need mice, and when might you skip straight to human-relevant models? How do you fund prevention research when the payoff is decades away? And what are the real risks of mandatory folic acid flour fortification, a policy Prof David argues deserves more scrutiny, given potential microbiome effects we don't yet fully understand.

Prof David also unpacks what the BSRA does day-to-day: from connecting researchers and lobbying government to running small grants and building bridges with clinicians and industry, and why he thinks the longevity field's biggest enemy isn't scepticism, it's overpromising.

Plus, we discover the most extreme longevity idea he's ever come across (involving spare parts — we'll leave it there).

Links:

https://www.durham.ac.uk/staff/david-weinkove/

Home - Magnitude Biosciences

HOME PAGE - BSRA

https://www.linkedin.com/in/david-weinkove-bab807b

In this episode:

00:00 Welcome to Beyond Longevity + Meet Prof. David Weinkove

02:40 From Physics to Bioscience: Career Origins & Model Organisms

04:29 The Breakthrough: How Bacteria (and Folate) Can Extend Worm Lifespan

09:12 Measuring Healthspan in C. elegans: Movement, Decline & New Tech

10:38 Why C. elegans? Fast Ageing, Whole-Organism Biology & Screening Power

12:19 Worms vs Mice: Similarity to Humans, Ethics, Cost & Experimental Variability

15:35 Translating Worm Findings to Humans: Microbiome Links, Exercise Paper & Next Steps

17:52 Funding the Science: UKRI, MRC vs BBSRC, and the Reality of Grant Constraints

20:52 Why Longevity Research Struggles for Support: Messaging, Hype & Prevention

28:39 BSRA’s Mission & the Five Pillars: Public Engagement, Advocacy, Fundraising, Translation

32:01 Breaking Down Silos: Making Longevity Research Useful (and Public)

34:07 Prevention Mindset: Why “Healthier for Longer” Isn’t Instant Gratification

36:15 When to Start Interventions: Metformin, Timing, and Trial Design Challenges

39:39 Why Magnitude Bioscience Exists: Fast Whole-Organism Ageing Screens

41:12 What Companies Test in Worms: From Candidate Drugs to 1,000-Compound Screens

42:48 Folic Acid Fortification & the Microbiome: A Potential Unintended Consequence

45:55 Should Government Engineer Health? Autonomy, Risk, and Public Policy Trade-offs

52:37 Ageing Demographics & the Case for Prevention-First Healthcare Investment

55:59 Making Longevity Matter to Everyday People + Rapid-Fire Q&A

01:01:47 Final Takeaways, Thanks, and Episode Wrap-Up

In this episode of Beyond Longevity, I sit down with Dr Mayoni Gooneratne, Founder and Medical Director of Human Health and Skin Fit Clinics, and Vice President of the British College of Functional Medicine. After years as an NHS colorectal and pelvic floor surgeon treating advanced disease, she made a decisive pivot into functional and preventative medicine with a sharp focus on women’s midlife health.

Dr Mayoni is frank about what she sees as the fault lines in modern healthcare: too little time to truly listen, a default toward symptom management over root-cause thinking, and a system designed to meet patients at crisis point rather than upstream. Her own definition of “good medicine” is different: deeper connection, individualised biology, and practical tools that help patients protect their own healthspan.

A major thread is perimenopause — why it is still under-recognised in conventional medicine and, surprisingly, even in the longevity conversation. She links this to the long-standing marginalisation of women in medical research, and the real-world consequences that follow. Her solution starts with “body literacy”: tracking patterns, paying attention to symptoms, using health data intelligently, and becoming an active participant in care and not simply waiting for a label.

We get into the specifics of her clinical approach: detailed history-taking and questionnaires, then targeted testing to confirm or disprove a hypothesis. She explains how she uses broad blood marker panels, aiming for optimal, not just “normal” ranges, stool testing to assess gut function, and nutrigenomics to understand how someone interacts with their environment. For anyone sceptical about functional medicine’s reputation for over-testing, her line is clear: testing should have a reason and early markers (like homocysteine and methylation issues) are worth catching before they become disease.

Her framework comes through in a powerful case study of a woman in her mid-forties post breast cancer treatment. The plan combined structured nutrition changes, Pilates to support bone health, and journaling to work through stored stress and anger, with measurable improvements in sleep and HRV.

Practical advice runs throughout: build a simple morning routine, prioritise nourishing food, choose “joyful movement” over punishment, reduce blue light and phone use at night, and rebuild real-world community. She also shares what she believes conventional medicine needs more of: stronger grounding in biochemistry and physiology, better nutrition education, and a far more serious commitment to women’s health.

Beyond the clinic, Dr Mayoni is also building infrastructure for the field. Through Human Health Professionals, she trains and mentors clinic owners to deliver longevity and wellness services responsibly. She also leads the Future Patient Congress and publishes Future Patient, quarterly, evidence-based resources magazine, designed to make current research more accessible and usable for clinicians and practitioners.

In the rapid-fire round: her single most important longevity adjustment, what she wishes she had known before leaving surgery, and what it really means to extend healthspan - not just lifespan.

BCFM College of Functional Medicine

Human Health™ by The Clinic | Functional Medicine in London

The Clinic by Dr Mayoni - Integrative Skin Care Clinic in London

Redefine Healthgevity and Metabolic Wellness | Human Health Professionals

Future-proofing patients’ health - Future Patient

00:00 Welcome to Beyond Longevity + Meet Dr. Mayoni Gooneratne

00:45 From NHS Surgery to Prevention: Why Patients Reach Crisis Point

06:01 What “Good Medicine” Looks Like: Time, Listening, and Healing Space

10:47 Why Perimenopause Is Still Overlooked (and Why It Matters for Longevity)

12:36 Body Literacy & Wearables: Turning Symptoms into Useful Data

14:47 Gaslighting, Doctor Google, and Empowering Women to Self-Advocate

17:39 Longevity Isn’t Just for Biohackers: Women’s Health as a Public Health Priority

20:42 Testing in Functional Medicine: History First, Then Blood, Gut & Nutrigenomics

24:16 “Too Much Testing?” Early Warning Markers, Methylation, and Going Upstream

26:43 Clinical Framework: How to Prioritise Systems When Everything Feels Off

29:22 The ‘House’ Analogy: Gut Foundations, Immune Roof, Stress Storms & Routines

32:45 Case Study: Post–Breast Cancer Optimisation—Metabolic Health, Protein, and Nervous System Reset

36:16 Healing Stored Anger: A Patient’s Nervous System Breakthrough

38:49 Perimenopause 101: Recognising the Early Signs & Symptoms

39:53 Food, Movement, Sleep: The Core Lifestyle Reset (Without Punishment)

42:10 Relationships, Boundaries & Reducing Toxic Inputs

45:18 Five Simple Longevity Adjustments: Morning Routine, Nutrition, Phone, Community

48:47 What Conventional Medicine Could Change Now (Nutrition + Women’s Health Education)

51:23 Why She Left Surgery: The Wake-Up Call on Reactive Healthcare

56:09 Building New Systems: Human Health, Future Patient Congress & Magazine

57:47 Training Clinicians: N=1 Medicine, Critical Appraisal & Practical Protocols

01:06:22 Rapid-Fire Longevity Q&A + Final Takeaways on Healthspan

He shares the path that led him here: a childhood ambition to become a GP, an early pull toward technology, and a personal family experience with chronic disease that clarified why the current model is failing both clinicians and patients. We talk candidly about GP burnout, time pressure, and why meaningful lifestyle support is so hard to deliver at scale.

Two data points frame his urgency:

-The Lancet Standing Commission’s 2024 report estimates that around 45% of dementia cases are potentially preventable by addressing 14 modifiable risk factors across the life course.

-A 2018 JAMA Network Open cohort study of 122,007 adults undergoing treadmill testing found cardiorespiratory fitness was inversely associated with long-term all-cause mortality, with a median follow-up of 8.4 years and no observed “upper limit” of benefit.

Dr Angus then walks through the two-part platform he is building:

1. A clinician-facing tool that helps generate chronic disease and preventive-care plans (including areas such as diabetes, hypertension, and dementia prevention).

-A patient-facing app designed around daily check-ins, habit tracking, nudges, milestones, and adherence dashboards — aiming to “close the accountability loop” between appointments giving clinicians the data they need and whilst keeping patients genuinely engaged with their own health in-between appointments

We also dig into what responsible clinical AI looks like in practice: hallucination risk, governance, compliance, and the line between augmentation and undermining the clinician–patient relationship. And we explore whether tools used in elite sport (including dynamometry for strength and fatigability) could become more relevant in ageing and sarcopenia care — including for patients using GLP-1 medications.

Dr Angus is clear about where things stand today: the app has had a very promising soft launch, clinician feedback driving iteration, early NHS pilot conversations, and outcomes data still being gathered. The episode closes with a sober assessment of where healthcare may be heading without greater patient empowerment — and a reminder that many of the biggest longevity gains are still driven by environment and lifestyle, not expensive interventions.

Rapid-fire highlights: why passion beats rigid planning, the single habit he prioritises most (sleep), what he would have done if medicine had not worked out, and why a simple daily gratitude practice can have outsized downstream effects.

Links:

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission

Association of Cardiorespiratory Fitness and Mortality Among Adults Undergoing Exercise Treadmill Testing

GeneralPractice.AI | Healthcare

Dr. Angus Perry - PAP - Pioneered Athlete Performance

https://uk.linkedin.com/in/dr-angus-perry-b49918128

In this episode:

00:00 — Welcome + introducing Dr Angus Perry, GP and clinical AI builder

01:39 — Origin story: why general practice, early tech roots, and high-performance medicine

03:26 — Why standard GP wasn't enough: chronic disease, system limits, and burnout

05:12 — The personal wake-up call: family experience and lifestyle-driven disease

08:55 — From experiments to product: early LLM tools and the lifestyle research that changed everything

10:52 — The evidence for prevention: dementia risk, fitness and mortality

13:12 — Introducing the platform: clinician tool and patient app for behaviour change

14:07 — Patient activation and empowerment: making people the CEO of their own health

15:57 — How the app works: risk factors, activation scoring, check-ins, and accountability loops 19:26 — Early launch feedback, adoption questions, and the road to NHS pilots

21:05 — What's next: AI agents, EHR integration, and removing workflow friction

22:56 — Clinician concerns about AI: augmentation vs replacement, and can AI extend healthspan? 25:08 — ChatGPT for health: useful, but the doctor–patient bond still matters

26:03 — What responsible AI means in healthcare: governance, risk, and regulation

27:38 — Does technology change how he practises as a GP?

28:20 — From Formula One to primary care: treating patients like elite athletes

31:40 — Performance technology that could reach clinics: muscle testing and the realities of G-force data

33:25 — Dynamometry explained: measuring strength, imbalances, and fatigability

35:41 — Why muscle mass is a longevity cornerstone — and how it declines

38:01 — Where GP and preventive medicine are headed in five years

40:08 — Is longevity medicine only for the wealthy? The 70/15/5 reality

43:28 — Rapid-fire advice and final takeaways on making innovation practical

Beyond Longevity is a deep-dive podcast exploring the cutting edge of longevity science. Each episode features insightful discussions with leading experts who share their latest findings, innovative studies, and practical applications to enhance our approach to longevity. The show translates complex research into clear, thoughtful discussions, decoding the future of ageing one conversation at a time.

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