Precision Medicine Made Simple

Surviving Cancer in a System That Wasn’t Built for You

Mon, 02 Feb 2026 01:00:00 -0800

What happens when a highly motivated patient meets a healthcare system that’s… not built for patients? In this episode, Kathy Giusti joins Taylor Cu and Dr. William Stanford to break down why cancer care can feel impossible to navigate—and what patients can do to take control of decisions, timelines, and outcomes.

Kathy shares how her diagnosis pushed her into “research mode,” how she identified the right myeloma centers before Google existed, and why personalization in cancer care is moving from “tumor type” to the underlying biology. She also gets real about trust: when patients can’t access their doctors or get answers beyond a 15-minute visit, trust erodes fast.

Key mindset shift: being informed isn’t “being difficult”—it’s survival. As Kathy puts it, the goal is to learn how to get the best medical advice, not replace your doctor.

Key Takeaways:

How patients can build the right care team and choose specialists in a complex cancer system
Why trust breaks down in healthcare and how limited access impacts patient outcomes
The difference between personalized medicine and precision medicine in real-world care
How genomics and epigenetics are reshaping cancer classification and treatment decisions
How to use AI and digital tools to prepare for doctor visits and support shared decision-making
The core ideas behind Kathy Giusti’s 12-step framework for patients and caregivers navigating cancer

In This Episode:

[00:00:00] Why patients lose trust in cancer care
[00:02:12] Kathy Giusti’s diagnosis + why she turned to advocacy
[00:05:54] The hardest early step: choosing the right team/center
[00:07:48] Identical twin insight + transplant-era decision-making
[00:09:48] Finding true specialists (and why it changes everything)
[00:12:51] Epigenetics, family patterns, and future cancer classification
[00:16:32] “Cure cancer” optimism vs the access reality
[00:18:10] Prevention, screening, and why people still avoid action
[00:21:15] Finding a great primary care doctor (and why it’s hard)
[00:25:46] One system vs fragmented care: coordination wins
[00:29:20] What precision medicine still gets wrong: clarity + language
[00:31:20] Trust, influencers, and using your time with doctors wisely
[00:36:00] Kathy’s book: Fatal to Fearless + the 12-step framework
[00:41:16] Using AI carefully: “prompt wisely” + trusted sources
[00:48:36] How to reach Kathy + closing thoughts

Notable Quotes

“The first step in cancer is often the hardest—deciding where to go, who’s your team.” [00:07:09]
“Patients end up wasting their 15 minutes doing administrative work.” [00:33:12]
“I think the trust issue overflows because the system is so broken.” [00:31:29]

Our Guest

Kathy Giusti was diagnosed with multiple myeloma at 37 and given three years to live—nearly 30 years ago. She co-founded the Multiple Myeloma Research Foundation (MMRF), helping accelerate drug development and improve outcomes for patients. She’s advised U.S. Presidents on cancer research and shares practical guidance for patients and caregivers navigating complex care.

Resource and Links

Kathy Giusti

https://www.kathygiusti.com/

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

This episode is sponsored by Biography Health — where DNA-powered healthcare is designed just for you. Biography Health is a HIPAA-compliant precision medicine platform that equips providers with AI-driven recommendations powered by your genetics, health history, and clinical insights — all while keeping data private, secure, and independent from large EHR systems.

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Sleep, HRV & Longevity: What Your Data Really Means with Dr. Mohammad Jarbou

Mon, 08 Dec 2025 01:00:00 -0800

In this episode of Precision Medicine Made Simple, we continue our discussion with Dr. Mohammad Jarbou from Episode 33, where we first explored the significance of VO₂ Max testing and its role in personal health optimization. Now, we dive deeper into the importance of sleep health, heart rate variability (HRV), and the insights provided by sleep studies.

Dr. Jarbou breaks down how HRV can be a valuable indicator of overall health and recovery, highlighting its connection to sleep quality and longevity. He also provides a closer look at mild sleep apnea, its effects on well-being, and how lifestyle interventions can help prevent the condition from progressing.

With actionable advice on improving sleep hygiene and the science behind REM sleep rebound, this episode offers valuable insights for those looking to optimize their sleep and overall health through a precision medicine approach.

Key Takeaways:

HRV reflects the balance between “fight or flight” and “rest and digest”—high HRV = good recovery.
High REM percentage can signal sleep deprivation, not “better sleep.”
Mild sleep apnea (AHI 5.6) is common and often doesn’t require CPAP in young, healthy patients.
Consistent sleep and wake times matter more than “making up sleep” with naps.
Sleep, fitness, and recovery exist in a cycle—fix one, improve the others.

In This Episode:

[00:00:00] HRV explained: stress, recovery, and sleep’s role
[00:02:19] Taylor sets the stage: VO₂ max test and sleep study follow-up
[00:05:33] Home sleep study setup, devices, and first-night discomfort
[00:07:59] In-lab sleep studies vs home sleep tests
[00:10:35] 4–3–2–1 sleep hygiene rule and real-life challenges
[00:13:18] HRV, alcohol, and what readiness metrics can and can’t tell you
[00:16:44] Total sleep time: why 5–6 hours is Taylor’s “first problem”
[00:18:30] High REM percentage and REM rebound from sleep deprivation
[00:20:00] Deep sleep vs REM: what truly restores your body
[00:24:33] AHI, 3% vs 4% oxygen drop, and Taylor’s mild sleep apnea
[00:29:32] Snoring, sleeping on your back, and positional therapy
[00:35:42] Naps, “social jet lag,” and protecting your sleep drive
[00:40:28] When to repeat sleep studies and add body composition (DEXA)
[00:43:05] Taylor’s takeaways and next step: VO₂ max deep dive in a future episode

Notable Quotes:

“REM sleep isn’t the restorative stage—deep non-REM sleep is where your body really recovers.” – Dr. Jarbou
“If your HRV is low in the morning, it’s often your body telling you it didn’t get the recovery it needed.” – Dr. Jarbou
“Most people don’t need fancy tests—they need better sleep structure and consistency.” – Dr. Jarbou
“Mild sleep apnea doesn’t mean treatment right away. Fix the basics first.” – Dr. Jarbou

Our Guest

Dr. Mohammad Jarbou is a physician with over 20 years of experience in pulmonary medicine, critical care, sleep medicine, and clinical informatics. He is the co-founder of the Longevity Clinic, a practice dedicated to proactive, personalized care aimed at optimizing health and preventing chronic diseases. Dr. Jarbou combines genetic testing, fitness assessments, and sleep optimization to create individualized wellness plans that promote health span and longevity.

Resource and Links

Dr. Mohammad Jarbou

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Inside the Membership Model That’s Making Healthcare Personal Again

Mon, 10 Nov 2025 02:00:00 -0800

The traditional healthcare system is breaking under the weight of burnout, short appointments, and profit-driven incentives, and Dr. Adam Wheeler has lived it from the inside. After losing a patient and realizing that all his creative energy was going into improving metrics instead of improving lives, he decided to build something radically different.

In this episode of Precision Medicine Made Simple, recorded live at Bigtree Medical in Columbia, Missouri, Dr. Wheeler joins host Taylor Cu and co-host Dr. William Stanford to share how he reimagined primary care from the ground up. His direct primary care network now serves more than 13,000 patients with a model built on unlimited time, transparent pricing, and authentic, patient-centered relationships.

You’ll hear how Dr. Wheeler’s model leverages nurse practitioners to expand access, integrates genetic and metabolic testing to personalize care, and embraces patient-requested treatments such as testosterone therapy, compounded GLP-1s, IV infusions, and preventive protocols. He also discusses how AI and shared decision-making empower patients to take control of their health, creating a system that rewards outcomes instead of volume.

This conversation explores what it truly takes to make healthcare personal again and why the future of medicine belongs to those willing to rebuild it from trust, data, and compassion.

Key Takeaways

Why Dr. Wheeler walked away from the traditional insurance model
How the direct primary care (DPC) membership system works and why patients love it
The role of nurse practitioners in solving the physician shortage
How Bigtree trains new NPs to lead with empathy and precision
Why shared decision-making is critical to modern medicine
What peptides, testosterone therapy, and GLP-1 medications mean for personalized care
How AI tools are empowering, not replacing, doctors
Why genetic and metabolic testing helps patients “know the fight they’re fighting”
The real difference between health span and lifespan and how to extend both
What the future looks like when healthcare becomes proactive instead of reactive

In This Episode

[00:00] Turning points in medicine
[01:17] Intro to Precision Medicine Made Simple
[02:39] Meet Dr. Adam Wheeler
[05:49] Membership model explained
[07:23] Bigtree care models
[08:19] Scaling intimacy in care
[08:48] Direct vs. concierge care
[09:51] Innovative patient care
[31:34] Genetics and cancer risk
[33:11] Personalized medicine
[34:06] Motivational interviewing
[35:11] Prostate cancer and genetics
[49:50] AI in healthcare
[53:01] AI’s role in medicine
[56:39] Bigtree Medical vision
[57:48] Final thoughts

Notable Quotes

[05:43] “It’s really sad that all this creative energy is going to juicing the numbers, as opposed to taking care of people.” — Dr. Adam Wheeler
[05:24] “We allow our patients to leave our practice at any time. If we do a bad job, they’re supposed to leave, and if we do a good job, they stay.” — Dr. Adam Wheeler
[14:27] “The direct pay model absolutely changes your incentives as a doctor… it forces you to care about the things patients actually care about.” — Dr. Adam Wheeler
[38:21] “There’s nothing you can do about the Lp(a), but you need to really optimize all of your other numbers.”— Dr. Adam Wheeler
[55:19] "I think before we have AI replacing me, we're gonna have me enabled with AI." — Dr. Adam Wheeler

Our Guest

Dr. Adam Wheeler is a board-certified pediatrician and the founder of Bigtree Medical, a membership-based direct primary care practice based in Columbia, Missouri. Under his leadership, Bigtree serves over 13,000 patients and continues to expand access to affordable, compassionate, and high-quality healthcare. He has been recognized as Missouri’s Best Young Physician (2019) and Entrepreneur of the Year (2021) for his innovation in healthcare delivery.

Resources and Links

Dr. Adam Wheeler

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Optimizing Health Span: How Fitness, Sleep, and Genetics Shape Longevity

Mon, 27 Oct 2025 02:00:00 -0800

In this episode of Precision Medicine Made Simple, we’re joined by Dr. Mohammad Jarbou, co-founder of the Longevity Clinic. Dr. Jarbou, a board-certified physician in pulmonary medicine, critical care, sleep medicine, and clinical informatics, discusses how his clinic uses a holistic approach to aging and health span. The clinic focuses on prevention and early detection, utilizing personalized medicine, genetic testing, fitness plans, and sleep optimization.

Dr. Jarbou explains how cutting-edge practices, such as VO2 max testing, personalized nutrition, and genetic evaluations, help optimize long-term health. He also highlights the importance of muscle mass and good sleep hygiene for aging well, and how these factors are integral to preventing chronic diseases.

Key Takeaways:

VO2 max testing is an excellent predictor of longevity and health span.
Muscle mass is critical for long-term health and quality of life.
Genetic testing helps guide personalized wellness plans and prevent chronic illness.
Sleep hygiene plays a significant role in overall health, affecting everything from energy to metabolism.
Personalized health strategies should incorporate fitness, nutrition, and genetics to achieve optimal wellness.
Prevention of chronic conditions like diabetes, Alzheimer’s, and sleep apnea can be achieved with early detection and lifestyle modifications.

In This Episode:

[00:00] – Introduction to Dr. Mohammad Jarbou and the Longevity Clinic
[05:00] – How the clinic’s focus on prevention and early diagnosis led to personalized care
[10:00] – The significance of VO2 max testing and wearable technology for tracking fitness
[15:00] – The importance of muscle mass and weightlifting for longevity
[20:00] – The role of genetic testing in guiding personalized health strategies
[25:00] – How sleep quality affects overall health and Dr. Jarbou’s tips for better sleep
[30:00] – The benefits of personalized nutrition and building sustainable habits
[35:00] – Addressing chronic conditions with early intervention and prevention
[40:00] – Hormone replacement therapy and its role in health optimization for longevity
[45:00] – How genetic testing can help identify risks for chronic diseases like Alzheimer’s

Notable Quotes

"Longevity is not just how long you live, but the quality of life you have along the way." – Dr. Mohammad Jarbou
"Muscle mass is critical for both physical function and longevity." – Dr. Mohammad Jarbou
"Prevention should be the foundation, not an afterthought, when it comes to aging and health." – Dr. Mohammad Jarbou
"You can't just focus on one area of health. Fitness, nutrition, sleep, and genetics all play an essential role in how you age." – Dr. Mohammad Jarbou
"Small changes in habits can have a huge impact on your longevity." – Dr. Mohammad Jarbou

Our Guest

Resource and Links

Dr. Mohammad Jarbou

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Understanding Polygenic Risk Scores: A Deep Dive into Genetics and Predictive Healthcare

Fri, 10 Oct 2025 02:00:00 -0800

In this episode of Precision Medicine Made Simple, we’re joined by Dr. Jeff Gulcher, co-founder of Decode Genetics and current leader at Galateo Bio. Dr. Gulcher shares his vast experience in the field of genomics and precision medicine, covering everything from polygenic risk scores (PRS) to the challenges of integrating diverse genetic data into predictive healthcare.

Dr. Gulcher takes us back to the early days of genetic research with Decode Genetics, where his team pioneered genome-wide association studies (GWAS) in Iceland. He dives into the development of PRS and the challenges of improving disease prediction models, especially by ensuring they are accurate across diverse populations.

In addition, Dr. Gulcher discusses his personal journey with prostate cancer and how polygenic risk scores helped predict his elevated risk at an early age. The episode also covers how genomics, when combined with other clinical data, can revolutionize preventative healthcare.

Key Takeaways:

Polygenic risk scores (PRS) are essential in predicting the risk for diseases like cancer and cardiovascular conditions.
The development of PRS is revolutionizing preventative healthcare, especially when there's no family history.
Ancestry-aware PRS models are crucial, as current models are mainly based on European populations.
Dr. Gulcher’s personal experience with prostate cancer demonstrates the power of early genetic screening.
Combining genetic data with clinical risk factors can provide a more accurate disease risk prediction.
The future of PRS lies in the integration of AI and better data representation across diverse populations.

In This Episode:

[00:00] – Introduction to Dr. Jeff Gulcher and the significance of polygenic risk scores
[05:00] – Dr. Gulcher’s background and the founding of Decode Genetics
[10:00] – How polygenic risk scores work and their application in predicting diseases
[15:00] – The challenge of making PRS models work for non-European populations
[20:00] – Dr. Gulcher's personal story: how early genetic testing saved his life
[25:00] – The role of genetic data in determining the risk for common diseases like prostate cancer
[30:00] – The importance of combining genetic risk with lifestyle factors in disease prevention
[35:00] – The potential of AI in refining polygenic risk score models
[40:00] – The challenges of integrating genetic data into real-world clinical practice
[45:00] – How diverse genetic data will help improve precision medicine globally

Notable Quotes:

“Polygenic risk scores help us understand how much our genes contribute to disease, but they are just one piece of the puzzle.” – Dr. Jeff Gulcher
“Genetics isn’t destiny, but it’s an important part of the story, especially when combined with other risk factors.” – Dr. Jeff Gulcher
“We need to build more inclusive data sets so that precision medicine works for everyone, not just for those of European ancestry.” – Dr. Jeff Gulcher
“Personalized healthcare is about understanding each individual’s unique genetic makeup and how that impacts their risk for disease.” – Dr. Jeff Gulcher
“Polygenic risk scores are not diagnostic, but they can offer a more accurate prediction for individuals at risk.” – Dr. Jeff Gulcher

Our Guest

Dr. Jeff Gulcher is a co-founder of Decode Genetics and the Chief Scientific Officer at Galateo Bio. With over 200 publications and years of pioneering work in genetics, he has been instrumental in shaping the field of genomic medicine. Dr. Gulcher’s current work at Galateo Bio focuses on building a global biobank with diverse genetic data to advance precision medicine, particularly for underserved populations.

Resource and Links

Dr. Jeff Gulcher

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Navigating Healthcare Complexity: DIY Testing, AI, and Building Your Trusted Care Team

Fri, 26 Sep 2025 02:00:00 -0800

In this episode of Precision Medicine Made Simple, we’re joined by Lucy Janoyan, the Chief Operations Officer and Chief Strategy Officer at Biography Health. Together with Taylor Cu, Lucy dives into a wide-ranging discussion on the state of healthcare, DIY testing, and the future of personalized care.

Lucy and Taylor reflect on their experience at Rosetta Fest, where they explored the complexities of the healthcare system, the growing trend of employer-sponsored healthcare, and the role of digital health platforms in improving care delivery. They also discuss the challenges of managing family health data, the importance of building trusted care teams, and the increasing role of DIY health tools and AI in the personal health journey.

Through personal anecdotes, Lucy shares her perspective on how healthcare consumers are navigating the fragmented system, the need for better data transparency, and why it’s crucial to combine innovative technologies with trusted healthcare professionals.

Key Takeaways:

The complexities of the current healthcare system make it hard to deliver personalized care efficiently.
The rise of DIY health testing and the role of AI in managing health data raises concerns around data security, accuracy, and the need for expert validation.
Employers are becoming more involved in providing innovative health benefits, but challenges remain for smaller businesses in offering comprehensive plans.
How fragmented health data across different systems impacts patients and caregivers, and why consolidation and integration are essential.
The importance of trusted care teams and providers, even in an age of digital health platforms and self-directed care.

In This Episode:

[00:00] Introduction to the challenges of navigating healthcare and the role of employers in healthcare
[05:00] Reflections on Rosetta Fest and the conversations around transparency, costs, and improving outcomes
[10:00] The rise of DIY health testing and its impact on trust in providers and healthcare plans
[15:00] How employers are evolving their healthcare offerings and the rise of self-insured companies
[20:00] The importance of consolidating fragmented health data for easier patient navigation
[25:00] The limits of AI in healthcare and why expert validation is still necessary
[30:00] Managing family healthcare data and the importance of self-advocacy
[35:00] Exploring the power of genetics in managing health risks and creating personalized care plans
[40:00] The importance of having a trusted care team in the DIY health era and the future of personalized care

Notable Quotes

“We need to combine AI and digital health tools with trusted providers to ensure the data we’re using is accurate and impactful.” – Lucy Janoyan
“More data doesn’t always equal better decisions if we don’t know how to use it. It’s about action, not just information.” – Taylor Cu
“Your genes are not your destiny. We have the power to influence our health with the right information and the right team.” – Lucy Janoyan
“We’re moving toward a more holistic care model, but we need to make sure it’s also consolidated and accessible.” – Lucy Janoyan

Our Guest

Lucy Janoyan is the Chief Operations Officer and Chief Strategy Officer at Biography Health. With a strong background in healthcare and a deep understanding of the complexities of the system, Lucy leads efforts to make precision medicine more accessible, actionable, and personalized for individuals and their care teams.

Resource and Links

Lucy Janoyan

https://www.healthtechalpha.com/person/lucy-janoyan

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Polygenic Risk Scores 101: A Key to Predicting and Preventing Complex Diseases

Mon, 08 Sep 2025 02:00:00 -0800

In this episode of Precision Medicine Made Simple, we welcome back Dr. Yelena Bykhovskaya, the Chief Scientific Officer at Biography Health, for a deep dive into polygenic risk scores (PRS) and their emerging role in precision medicine. Dr. Bykhovskaya breaks down the complexities of genetics and its application in clinical practice, focusing on how polygenic risk scores can be used to assess an individual's risk for common complex diseases.

We discuss the evolution of genetics in healthcare, how PRS differs from monogenic testing, and why the accuracy and predictive power of these scores are becoming increasingly important. We also address some of the challenges in applying PRS across different populations and the future potential of genetic risk scores in personalized healthcare.

Key Takeaways:

Polygenic risk scores are a powerful tool for assessing genetic predisposition to complex diseases like heart disease, Alzheimer’s, and more.
PRS are calculated using multiple genetic variants, not just one, making them useful in understanding complex traits.
While still evolving, PRS are becoming more accurate, especially with the incorporation of data from diverse populations.
Understanding PRS can help prevent diseases before they manifest, offering proactive healthcare solutions.
The challenges and benefits of integrating PRS into clinical practice, and how the field is rapidly advancing.

In This Episode:

[00:00] Introduction to polygenic risk scores and their relevance in precision medicine
[05:00] How the Human Genome Project and next-generation sequencing revolutionized genetics
[10:00] Explaining the difference between monogenic and polygenic diseases
[15:00] The limitations of current PRS models and how they’re improving over time
[20:00] Why PRS is especially useful for assessing cardiovascular risk and other common conditions
[25:00] The impact of ancestral diversity on PRS and how researchers are making improvements
[30:00] What it takes for PRS to move from research to clinical use
[35:00] The potential for PRS to inform more personalized treatment plans
[40:00] Dr. Bykhovskaya’s personal experience with blood pressure medication and how PRS could have helped
[45:00] How precision medicine is changing the way we think about healthcare

Notable Quotes:

“Polygenic risk scores are not just about predicting the future, they’re about empowering people to take control of their health today.” – Dr. Yelena Bykhovskaya
“You can't just focus on a single gene; it's about the whole picture, understanding how multiple genetic factors contribute to disease risk.” – Dr. Yelena Bykhovskaya
“Genetics is a moving field, and as we gather more data, the accuracy and usefulness of PRS will continue to improve.” – Dr. Yelena Bykhovskaya
“Personalized medicine is about understanding you as an individual and tailoring healthcare to your specific needs, not just your symptoms.” – Dr. Yelena Bykhovskaya

Our Guest

Dr. Yelena Bykhovskaya is the Chief Scientific Officer at Biography Health, where she leads efforts to integrate genetic insights into healthcare. With a background in genetics and a passion for precision medicine, Dr. Bykhovskaya is at the forefront of innovations in how we understand genetic risk factors and apply them to patient care.

Resource and Links

Dr. Yelena Bykhovskaya

https://www.linkedin.com/in/yelena-bykhovskaya-791996a/

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Why Performance Medicine Matters More Than Prevention

Mon, 25 Aug 2025 02:00:00 -0800

In this episode of Precision Medicine Made Simple, we’re joined by Dr. Rich Joseph, a physician with a rare blend of expertise as both a strength and conditioning specialist and a competitive athlete. Dr. Joseph is the founder of VIM Medicine and the Board Chair of Vital Connections. He’s also a faculty member at Harvard Medical School and Brigham and Women’s Hospital, where he focuses on preventive medicine.

Dr. Joseph’s unique approach integrates performance medicine, which he defines as the capacity to bring energy and attention to what matters most in life. His philosophy blends athletic mindset and proactive health practices to help people achieve peak performance in all aspects of life—physical, mental, and emotional.

In this episode, we dive into his journey from athlete to physician, how he started VIM Medicine, and how performance medicine can optimize health and longevity. We also discuss the importance of mindset, recovery, and behavior in achieving long-term wellness.

Key Takeaways

The concept of performance medicine and its relevance to overall well-being.
How performance-based healthcare goes beyond disease treatment to emphasize proactive, personalized care.
The importance of behavioral grounding and experimentation in health optimization.
How to use performance metrics like VO2 max and strength to monitor and improve health.
The evolution of health insurance and its role in a more proactive, patient-centered care model.
The growing field of longevity and the need for more balance in the conversation around aging

In This Episode

[00:00] Introduction to Dr. Rich Joseph’s approach to performance medicine
[05:15] Transitioning from athletic training to a medical career
[10:00] The importance of a mindset focused on progress over perfection
[14:30] Starting VIM Medicine and the integration of exercise into healthcare
[20:00] The role of recovery and mindset in optimizing longevity
[25:00] Exploring peptides, supplements, and managing the noise in health trends
[30:00] Biomarkers: What should you focus on for long-term health?
[35:00] The difference between functional medicine, longevity medicine, and personalized care
[40:00] Vital Connections and the effort to address healthcare inequities in Boston
[45:30] Dr. Joseph’s vision for the future of healthcare and his practice’s growth

Notable Quotes

“Health is an asset, something you have to strategically manage and invest over the long term.” – Dr. Rich Joseph
“You can’t just treat the symptoms; you have to optimize performance to live well.” – Dr. Rich Joseph
“Prevention is not sexy, but performance is something everyone can get behind.” – Dr. Rich Joseph
“You have to pair stimulus with recovery to create adaptation.” – Dr. Rich Joseph

Our Guest

Dr. Rich Joseph is a Harvard-trained internist, founder of VIM Medicine, and Chief Medical Officer at Restore Hyper Wellness. With a background in strength and conditioning, he has created a unique model of Performance Medicine that combines athletic principles with healthcare. His approach emphasizes proactive health strategies, personalized wellness, and performance optimization. Dr. Joseph also leads Vital Connections, a nonprofit focused on improving health equity and community well-being.

Resources and Links

Dr. Rich Joseph

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

7 Paradigm Shifts That Will Rewrite Medicine

Mon, 11 Aug 2025 02:00:00 -0800

Most of today’s healthcare still treats problems after they happen. Dr. Leroy Hood thinks that needs to change. In this episode of Precision Medicine Made Simple, he explains how genomics, regular health tracking, and AI can shift the focus to preventing disease before it starts.

Dr. Hood is one of the scientists who helped build the automated DNA sequencer that powered the Human Genome Project. He also founded the Institute for Systems Biology. He has worked across research, government, and healthcare to push ideas that were unpopular at the time but are now standard practice.

You’ll hear how he went from a professor at Caltech to building new departments, starting research institutes, and working with governments around the world to change how healthcare works.

He also explains the idea of P4 medicine: predictive, preventive, personalized, and participatory care and why most of the healthcare system isn’t built to support it yet.

Key Takeaways

Seven shifts that shaped Dr. Hood’s career and could change medicine
Why most healthcare money goes to chronic disease and how to cut that
How genome and phenome data can find diseases years before symptoms
What polygenic risk scores mean for different ethnic groups
How AI helps doctors create personalized care plans
How useful data can slow aging, prevent Alzheimer’s, and support your health
Why chasing profits slows down U.S. healthcare
How kids in Seattle learn to manage their own health
Why commercial insurance may fail if it doesn’t adapt
How Tom Brady trained his brain to last longer and how you can apply that

In This Episode

[00:00] Introduction to Dr. Leroy Hood's journey
[01:49] The evolution of precision medicine
[03:11] Introducing Dr. Leroy Hood
[04:41] Dr. Hood's early career and challenges
[06:43] The birth of systems biology
[08:20] Pioneering cross-disciplinary research
[10:56] The Human Genome Project
[13:49] Establishing systems biomedicine
[22:51] The Luxembourg initiative
[23:45] Data-driven health insights
[30:42] Challenges with polygenic risk scores
[31:42] Ancestry and genetic variants
[32:52] Pharmacogenomics and drug response
[33:16] Rare diseases and carrier status
[34:57] Lifestyle genetics and athletic injuries
[36:18] Actionable possibilities in genomics
[38:27] Economic impact of chronic disease prevention
[39:04] Obstacles to deep health analysis
[40:48] Advancements in personalized medicine
[45:50] The future of health care and AI
[56:15] Brain health and cognitive function
[59:39] Conclusion and future topics

Notable Quotes

[00:00:39] "I decided “Big Data” was necessary to deconvolute the complexity of human biology. But the instrumentation for “Big Data” didn't exist at that point in time." — Dr. Leroy Hood
[00:11:41] "The big science of the genome project revolutionized so many fields of biology in profound ways that it's really quite remarkable." — Dr. Leroy Hood
[00:12:15] "The Human Genome absolutely transformed our understanding of how we can think about human biology." — Dr. Leroy Hood
[00:13:39] "If you really want to have fun with science, you can't do it at a place where people are criticizing two of the major thrusts in your laboratory." — Dr. Leroy Hood
[00:44:14] "Over the last 40 years, Americans extended their lifespan by 10 years. They didn't expand their health span by a single year." — Dr. Leroy Hood
[00:54:53] "I think the health care industry is going to have to adapt to a very different reality than they've adapted to now." — Dr. Leroy Hood
[00:55:05] "Imagine focusing on keeping people well and avoiding disease. I mean, that isn't how these people make money." — Dr. Leroy Hood
[00:58:21] "The brain is plastic, it can be changed." — Dr. Leroy Hood

Our Guest

Dr. Leroy Hood is a biologist and technologist. He led the development of the DNA sequencer that made the Human Genome Project possible. He has founded several research centers and published widely on systems biology and health monitoring. He now focuses on using genomics and phenomics to help people stay healthy longer.

Resources and Links

Dr. Leroy Hood

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

The Osteopathic Doctor Who Maps Your Genetics, Mental Health, and Body Systems

Mon, 28 Jul 2025 02:00:00 -0800

What does it really take to solve the medical mysteries most doctors dismiss? In this episode of Precision Medicine Made Simple, we sit down with Dr. Hengameh Monsef, DO, an internal medicine physician trained in high-acuity care, now reinventing how we treat chronic and complex illness through concierge precision medicine at Ascending Medicine.

She shares her journey from Iran to the U.S., from frustrated hospitalist to data-powered detective. We dive into how whole genome sequencing, pharmacogenetics, and old-school osteopathic wisdom come together in her practice and why some of the most impactful tools, like lymphatic drainage and myofascial release, are still off the radar in mainstream care.

This is a must-listen for clinicians rethinking their practice, patients frustrated by the status quo, and anyone curious about the intersection of science, culture, behavior, and care.

Key Takeaways

Why Dr. Hengameh Monsef left the hospital system after 20 years
The surprising science behind “alternative” practices like lymphatic drainage and fascia work
How she balances whole genome data with patient preference, culture, and compliance
What AI can’t replace in clinical decision-making (yet)
Why pharmacogenetics saves lives and should be routine, not optional
How concierge medicine works and why younger doctors shouldn’t rush into it
The role of genetics in mental health, depression, and drug sensitivity
What needs to change in politics and insurance for precision medicine to scale

In This Episode

[00:00] Introduction to experience in medicine and AI
[00:54] Welcome to Precision Medicine Made Simple
[02:17] Meet Dr. Hengameh Monsef
[03:25] Dr. Monsef' journey to medicine
[07:06] The philosophy of osteopathic medicine
[10:08] Challenges and rewards of concierge medicine
[18:01] Personalized medicine and patient care
[23:06] Exploring holistic and alternative therapies
[27:53] The dangers of sitting: why movement matters
[29:15] Holistic lifestyle interventions for chronic diseases
[29:51] Personalized medicine: the role of whole genome sequencing
[30:28] Understanding genetic variants and chronic conditions
[32:07] Acupuncture and genetic differences
[33:11] Screening for mental health issues
[34:23] Genetic links to depression and anxiety
[34:49] The importance of pharmacogenetics
[36:47] Challenges in traditional medicine and the role of AI
[40:10] The future of personalized medicine and patient empowerment
[46:49] Insurance companies and market forces
[48:56] The role of patients in shaping healthcare
[56:16] Advice for female immigrant physician entrepreneurs
[57:00] Conclusion and contact information

Notable Quotes

[08:38] "I think the more data we have, it's going to direct medicine to maybe a different route that are currently being taught in traditional medical schools." — Dr. Hengameh Monsef
[10:54] "When you become a physician, just that career is dedication. So I feel I'm dedicated to the patient. So it makes it even harder to balance family." — Dr. Hengameh Monsef
[11:23] "Why concierge medicine is growing is by just the fact that you're concierge, you tend to keep lower numbers. By lower numbers, you decrease the number of emergencies that could happen in a day." — Dr. Hengameh Monsef
[13:25] "If you're graduating early, it's not a good idea to do concierge medicine because you have to put some experience that, that learning that comes with experience." —Dr. Hengameh Monsef
[56:16] "I think first generation immigrant automatically most of them are part workers when you have to survive. Or they say necessity is the mother of all inventions." —Dr. Hengameh Monsef

Our Guest

Dr. Hengameh Monsef, DO is board-certified in internal medicine, with decades of experience in high-acuity settings. Now co-leading Ascending Medicine, she specializes in complex case management across chronic illness, autoimmune conditions, and mental health overlap—using genomics, lifestyle interventions, and osteopathic-informed care to go deeper than traditional 15-minute visits ever allow.

Resources and Links

Dr. Hengameh Monsef

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

The Hardest Part of Longevity Medicine According to This Stanford Doctor

Tue, 15 Jul 2025 06:00:00 -0800

What if your doctor could predict what will kill you—before it ever becomes a problem? In this episode of Precision Medicine Made Simple, we dive into the evolving landscape of longevity medicine and health AI with Dr. Hillary Lin, Stanford-trained internist, former oncologist, and co-founder of CareCore—a platform empowering wellness creators and brands to offer doctor-supervised, data-driven care.

Dr. Lin shares her personal journey from frustration with traditional medicine to building one of the most forward-thinking longevity platforms today. She discusses how we can sift through misinformation, integrate wearables, genetics, and proteomics, and balance the promise of AI with the human art of medicine.

If you're interested in the intersection of tech, behavior change, and personalized healthcare—or you're a clinician navigating this fast-changing world—this episode is a must-listen.

Key Takeaways

Why Dr. Lin walked away from oncology—and what that revealed about the limits of traditional medicine
How AI is helping doctors make sense of overwhelming health data (without replacing the human touch)
Why behavior change—not biomarkers—is still the hardest challenge in longevity care
What whole genome sequencing and proteomics are uncovering about health risk (and why family history still matters)
How mental health is shaped by biology, not just emotions—and what that means for future treatments
Why “more data” isn’t always better—and how the art of medicine guides what we actually do with it
How CareCore is bringing doctor-backed longevity tools to wellness creators, gyms, and health brands
Why longevity medicine must balance innovation with scientific rigor—and where influencers can help or hurt

In This Episode

[00:00] Dr. Lin’s background and intro to the show
[01:02] Leaving traditional medicine: oncology frustrations
[07:07] Curiosity, questioning incentives, and systemic change
[14:30] Wearables, data overwhelm, and near-future care
[19:21] Will AI replace doctors? Not likely—here’s why
[25:27] Behavior change, accountability, and lifestyle compliance
[28:40] Why common advice still matters—but needs personalization
[32:56] Dr. Lin’s take on Brian Johnson’s biohacking movement
[36:33] The importance of community and mental health in longevity
[43:39] Gut-brain connection and biological drivers of mental health
[47:01] How to build a personalized longevity baseline
[50:23] Genomics vs. real-world outcomes: a case study in family history
[55:44] AI-enabled care and the future of CareCore
[59:20] Influencer health, B2B partnerships, and responsible content

Notable Quotes

[01:02] "I realized somewhere along the way that I couldn't be a doctor in today's system and do the things that I hope to do. You have to maintain the mind of a child always in that you're asking why?" — Dr. Hillary Lin
[01:38] "Behavior change is the number one, most important and hardest thing to achieve. I think the art part of medicine is really knowing what to do with incomplete knowledge." — Dr. Hillary Lin
[08:09] "The curiosity was so important because it makes you push past a lot of deterrence... you have to really dig past that by continuously asking, well, why is it that way?" — Dr. Hillary Lin
[21:46] "I think there will always be a place for doctors slash healers. And the reason is humans love other humans." — Dr. Hillary Lin
[29:48] "I think the art part of medicine is really knowing what to do with incomplete knowledge.I always say start with figuring out what will kill you first.”— Dr. Hillary Lin
[34:55] "I think people should be re-energized about lifestyle changes. It's not new, but if he makes it seem like it's new, then cool, that's fine." — Dr. Hillary Lin
[55:59] "We are going to almost fully automate healthcare in the future, starting with the lower risk fields of course." — Dr. Hillary Lin

Our Guest

Hillary Lin, MD is the Co‑Founder & CEO of Care Core, a clinical platform that empowers wellness creators and brands to offer doctor‑supervised lab tests, prescriptions, and evidence‑based health products.

A Stanford‑trained internist with oncology experience at Columbia, she previously co‑founded Curio, a venture‑backed digital‑mental‑health platform.

Dr. Lin is an Aspen Health Fellow and advisor to innovation hubs at Stanford and Cornell, along with select health and longevity startups.

Through YouTube, LinkedIn, Instagram, TikTok (@hillarylinmd), her newsletter The Long Game, and the podcast The Longevity Show, she shares practical longevity science to help people extend their healthspan.

Resources and Links

Dr. Hillary Lin

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

The Side of Personalized Healthcare No One Talks About

Mon, 30 Jun 2025 01:00:00 -0800

In this episode of Precision Medicine Made Simple, hosts Dr. William Stanford and Taylor Cu sit down with Dr. Genise Fraiman, founder of Ascending Medicine and a trailblazer in concierge care. With over two decades of experience—from co-founding one of Cedars-Sinai’s top hospitalist groups to mentoring young physicians—Dr. Fraiman shares her personal and professional evolution toward a more human, proactive approach to medicine.

Together, they unpack the pressures of traditional practice, the emotional toll of hospital work, and Dr. Fraiman’s deeply personal experience navigating breast cancer risk without the genomic tools we now have at our fingertips. She also reveals how treating sleep apnea transformed her own health—and why even “healthy” patients shouldn’t ignore it.

This candid, wide-ranging conversation explores the promise (and pitfalls) of AI in healthcare, the art of vetting medical information, and what it really takes to start a concierge or precision-focused practice today. At its core, this episode is about reimagining the doctor-patient relationship—and reclaiming time, trust, and tailored care.

Key Takeaways

The untold toll of hospital-based medicine—and why Fraiman finally left it behind
What concierge care actually looks like in practice (and why it matters)
Why time is the most underrated tool in patient care
Dr. Fraiman’s decision to undergo a prophylactic mastectomy—and the missing genomic data that could’ve changed it all
How sleep apnea affects even lean, fit patients—and how CPAP changed her health
What patients should know about supplements, pseudoscience, and AI misinformation
How to vet a personalized medicine provider—and why the right “fit” matters more than ever
Dr. Stanford’s bold prediction: commercial health insurance will collapse within 10 years

In This Episode

[00:00] Introduction and initial questions
[00:59] Welcome to the podcast
[01:07] Guest introduction: Dr. Genise Fraiman
[01:55] Early career and meeting Dr. Stanford
[04:07] Building a hospitalist group
[04:34] Transition to concierge medicine
[05:52] Challenges and rewards of concierge medicine
[07:13] Personalized patient care
[13:50] Proactive vs. reactive medicine
[19:47] Personal health journey and genetic risks
[29:48] Sleep study reflections
[30:11] Challenges and adjustments with CPAP
[31:21] Exploring alternative treatments
[33:00] Navigating medical information and supplements
[38:02] The role of AI in healthcare
[42:44] Starting a concierge medical practice
[46:58] Insurance and healthcare costs
[52:32] Privacy concerns with genetic testing
[55:28] Finding the right medical provider
[57:42] Conclusion and contact information

Notable Quotes

[07:28] "What I found is I've been on all sides. I've been the patient, I've been the physician, I've been the family member. And it's a really horrible feeling to feel helpless in any of those situations."— Dr. Genise Fraiman

[14:33] “I think we were taught to be really great at being reactive physicians. But if we can take that same knowledge and be proactive—change the trajectory—that’s the name of the game.” — Dr. Genise Fraiman

[24:53] “If I had the genetic information then that I have now, the decision around my mastectomy would’ve been far less agonizing.” — Dr. Genise Fraiman

[27:50] “I failed my sleep study miserably… and I’m 5’3”, fit, and healthy. You can’t ignore the data.” — Dr. Genise Fraiman

Our Guest Dr. Genise Fraiman

Founder of Ascending Medicine, Dr.Fraiman brings over two decades of clinical leadership, including founding a leading hospitalist group at Cedars-Sinai and transitioning to concierge and precision medicine. A recognized advocate for truly patient-centered care, she is passionate about longevity, genomics, and building meaningful doctor-patient relationships that last.

Resources and Links

Dr. Genise Fraiman

Taylor Cu

Dr. William Stanford

https://www.linkedin.com/in/william-stanford-md-phd-facp

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

This Ex-Surgeon Is Reprogramming Aging with AI and Systems Science

Mon, 16 Jun 2025 06:00:00 -0800

We’re living in the age of health data overload—but how do you turn all those insights into real-life transformation? This episode of Precision Medicine Made Simple features Dr. Daniel Stickler, former vascular surgeon turned systems medicine pioneer, who’s leading the charge in longevity, AI-powered diagnostics, and cutting-edge clinical tools.

In this candid conversation with hosts Dr. Stanford and Taylor, Dr. Stickler opens up about the moment he walked away from surgery for good—and how it led to building an entirely new model of medicine. From continuous glucose monitors to full genome sequencing, from peptides to personalized AI agents, Dr. Stickler shares the emerging tools that are empowering both doctors and patients to move from disease management to proactive health optimization.

Whether you're a healthcare provider, tech innovator, or simply a wellness-curious listener, this episode will challenge your assumptions and give you a vision for the future of truly personalized care.

Key Takeaways

Why most modern medicine is built around postponing death, not optimizing life
How wearables like Garmin and UltraHuman reveal individual patterns (and change behavior fast)
The overlooked power of epigenetics—and why lifestyle still rules your genes
What peptides like BPC-157 and GLP-1 analogs are doing for healing, inflammation, and gut health
How Dr. Stickler uses AI to process patient data and create 50-page system-based care plans in minutes
Why “root cause” medicine might be an outdated myth—and what’s next

In This Episode

[00:00] Introduction
[00:14] Guest introduction: Dr. Daniel Stickler
[01:00] Dr. Stickler's journey into medicine
[03:19] Integrating wearable technology in medicine
[05:39] The impact of wearables on patient care
[12:38] Genetics and epigenetics in medicine
[22:21] Systems-based medicine explained
[27:08] The role of peptides in modern medicine
[30:58] Introduction to GLP-1 peptides
[31:30] Benefits and fine-tuning of semaglutide
[32:35] Exploring BPC-157 for recovery
[33:51] Oral vs. injectable BPC-157
[35:05] Potential downsides of BPC-157
[36:44] Wearable technology and recovery
[38:19] The future of medicine: AI and personalized care
[56:17] The role of physicians in the AI era
[57:17] Concerns about over-reliance on technology
[58:46] Recommended resources for providers and patients
[01:01:19] FDA's role in approving medical advancements
[01:03:42] Exosomes and young plasma therapy potential

Our Guest

Dr. Daniel Stickler is the Co-Founder and Chief Medical Officer of Apeiron Zoh and Mosaic Biodata, where he integrates wearable tech, AI, peptides, genetics, and systems thinking into personalized healthcare. A former high-volume surgeon, he now trains clinicians globally in longevity and performance medicine. He's also an advisor to Google and a recognized thought leader in human enhancement and optimization.

Resources and Links

Dr. Daniel Stickler

Taylor Cu

Dr. William Stanford

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

The Former ER Doctor Challenging How We Practice Medicine w/Dr. Sukhjit "Sarge" Takhar

Mon, 02 Jun 2025 06:00:00 -0800

The Former ER Doctor Challenging How We Practice Medicine w/Dr. Sukhjit "Sarge" Takhar

Primary-MD.com

Email: drtakhar@primary-md.com

Takeaways

Dr. Takhar emphasizes the importance of understanding the patient as a person.
Concierge medicine allows for more personalized and attentive care.
The healthcare system often limits the time doctors can spend with patients.
AI can assist in healthcare but cannot replace the human connection.
Precision medicine focuses on individual patient needs rather than population averages.
The integration of advanced diagnostics is crucial for effective patient care.
Healthcare professionals must navigate the challenges of the current system.
There is a growing need for democratization of advanced medical care.
Patients should be encouraged to take an active role in their health decisions.
The future of medicine will likely involve more personalized and preventive approaches.

Summary

In this episode of the Precision Medicine Made Simple podcast, hosts Taylor Cu and Dr. William P. Stanford engage with Dr. Sukjit "Sarge" Takhar, a pioneer in concierge medicine. They discuss the evolution of healthcare, the challenges faced by practitioners, and the importance of personalized patient care. Dr. Takhar shares his journey from traditional medicine to a more individualized approach, emphasizing the role of advanced diagnostics and the integration of AI in healthcare. The conversation highlights the need for a human connection in medicine, the significance of understanding patient backgrounds, and the future of precision medicine as it becomes more accessible and affordable. The episode concludes with advice for aspiring medical entrepreneurs and a discussion on the intersection of science and patient care.

Chapters

00:00 The Journey Begins: Personal Stories and Connections

02:32 From Traditional Medicine to Concierge Care

06:36 The Shift Towards Precision Medicine

10:50 Challenges and Opportunities in Healthcare

14:57 The Future of Health Monitoring and Diagnostics

25:57 Vitalist Bay: A Progressive Longevity Conference

26:23 Buyer Beware: Navigating Longevity Medicine Hype

27:37 Understanding Conflicts of Interest in Longevity Research

28:30 Metabolic Health: The Crisis and Its Implications

29:57 The Role of Direct-to-Consumer Tests in Health Decisions

31:42 Precision Medicine: Personalizing Health Strategies

33:21 AI in Medicine: The Human Advantage

35:33 The Evolution of AI in Healthcare

37:31 AI and Human Connectivity in Medicine

39:58 The Future of AI in Patient Care

47:53 Navigating AI Regulations in Healthcare

50:33 Advice for Aspiring Medical Entrepreneurs

51:19 The Challenges of Building a Practice

53:00 Staying Current in Medicine

56:20 The Importance of Precision Medicine

01:01:25 Personalized Health Recommendations

01:07:55 Building Trust with Patients

01:13:43 Navigating the Landscape of Health Claims

01:16:14 PMMS - New Outro - No Music.mp4

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Dr. William Stanford is co-founder of Biography Health. He began his career as a mechanical and aerospace engineer at Texas Instruments in 1982 while also pursuing his interest in aviation as a flight instructor and commercial pilot. In 1991, he pivoted into biomedical science and subsequently completed the combined M.D./Ph.D. physician-scientist training program at the University of California, Los Angeles, in 1998 and an internal medicine residency at UCLA in 2001. He is board-certified in internal medicine and is a Fellow of the American College of Physicians.

A pioneer in the field of hospital medicine, Dr. Stanford founded and led a 25-physician group of private practice hospitalists at Cedars-Sinai Medical Center in Los Angeles in 2002. After an extensive clinical career as the attending physician for over 100,000 patients, he was elected by his peers at Cedars-Sinai to be clinical chief of general internal medicine, serving in this capacity from 2017 to 2018. Inspired by recent advancements in biomedical science and medicine, Dr. Stanford completed professional certification through Stanford University’s Department of Genetics in 2018, further advancing his role as a true physician-scientist. Since 2018, he has provided genomic and precision medicine consultations through the Beverly Hills Institute for Precision Medicine, enhancing his role as a leading expert in the field.

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

Keywords

Precision Medicine, Concierge Medicine, Healthcare Innovation, Patient Care, AI in Medicine, Health Coaching, Genetic Testing, Personalized Medicine, Medical Entrepreneurship, Longevity

The Doctor Who Says Dialysis Is Preventable w/ Dr. David Moskowitz

Mon, 19 May 2025 06:00:00 -0800

In this episode, Dr. David Moskowitz shares how thousands of patients have avoided dialysis through genomic medicine — and why most kidney failure is preventable.

We dive deep into ACE genes, repurposed drugs like quinapril and ProGraph, and explore what genomic insights could mean for diseases like Alzheimer's and cancer.

Heads up: this one gets detailed with a lot of medical terminology. If you're curious but lost, drop the transcript into ChatGPT — it'll help translate the science.

Dr. David Moskowitz - genomed.com

Takeaways

Dialysis is preventable, and awareness is crucial.

Innovative approaches can challenge traditional medical practices.

ACE inhibitors should be the first line of defense in kidney health.

Genetic factors play a significant role in Alzheimer's disease.

Whole genome sequencing can provide insights into various diseases.

Repurposing existing drugs may offer new treatment avenues.

The healthcare system often resists change due to financial incentives.

Public health initiatives need to focus on improving outcomes.

Understanding the molecular basis of diseases can lead to better treatments.

Collaboration and communication in medicine are essential for progress.

Chapters

00:00 Introduction to Preventive Medicine and Genomics

04:53 The Journey to Preventing Kidney Disease

07:35 Innovations in Kidney Health: The Role of ACE Inhibitors

10:14 Challenges in the Healthcare System

12:45 The Impact of Lifestyle on Kidney Health

15:38 Exploring the Connection Between COVID-19 and Kidney Disease

17:50 The Future of Genomics in Preventive Medicine

20:10 Patient Empowerment and Navigating Healthcare

22:57 Key Takeaways

39:31 Exploring Whole Genome Sequencing in Alzheimer's

42:16 Iron Overload and Neurodegeneration

46:36 mTOR Pathway and Alzheimer's Treatment

48:29 Repurposing Drugs for Alzheimer's and Other Neurodegenerative Diseases

55:09 Genetic Risk Factors for Alzheimer's

57:00 Innovations in Cancer Detection

01:02:47 Differentiation Therapy in Cancer Treatment

01:08:38 The Importance of Personalized Health

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

What Jensen Huang Got Right About the Future of Healthcare w/Lucy Janoyan

Mon, 05 May 2025 06:00:00 -0800

In this episode, Dr. Stanford, Lucy Janoyan, and Taylor Cu reflect on key takeaways from the Precision Medicine World Conference — from AI’s role in understanding disease to the future of polygenic risk scores. They discuss the challenges of data validity, patient privacy, and the evolving role of patients and providers in a tech-driven healthcare landscape, including a highlight from NVIDIA CEO Jensen Huang on how AI is set to reshape the future of medicine.

Takeaways

The conversation around precision medicine has evolved significantly since 2019.

AI is transforming patient care and the practice of medicine.

The PMWC provided a more intimate setting for meaningful discussions.

There is a growing concern about the ethical implications of AI in healthcare.

The transition from research to clinical practice is crucial for precision medicine.

Economic factors play a significant role in the adoption of precision medicine.

Digital twins could revolutionize personalized healthcare.

Data privacy and patient ownership are critical issues in genomic sequencing.

The insurance industry faces challenges in adapting to precision medicine.

The future of healthcare will be dramatically different in the next decade.

Chapters

00:00 Introduction to Precision Medicine and Conference Insights

05:22 Evolution of Precision Medicine Discussions

08:30 AI's Role in Healthcare Transformation

11:35 Challenges in Data Validity and Clinical Adoption

14:17 The Future of Polygenic Risk Scores

17:27 Optimism vs. Pessimism in Precision Medicine

20:26 Insurance and Healthcare Delivery Paradigms

23:31 Digital Twins and Their Impact on Precision Medicine

41:44 The Future of AI in Medicine

44:56 Understanding Aging and Disease Pathways

46:54 The Role of AI in Autonomous Science

48:40 Holistic and Precision Medicine

52:49 Data Privacy and Patient Governance

56:55 Concerns Over Genome Sequencing

01:02:13 The Global Landscape of Genomic Data

01:05:42 The Democratization of Precision Medicine

01:43:32 Introduction to Precision Medicine

01:43:32 The Importance of Personalized Health

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Sponsored by: Biography Health

If you're a provider ready to bring precision medicine into your practice, visit BiographyHealth.com to learn more.

Or, if you're a patient who wants your doctor to explore this, point them our way — we’ll help them bring personalized healthcare to life.

We Want To Hear From You For Season 2

Mon, 13 Jan 2025 06:00:00 -0800

Podcast Suggestion Survey

When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky

Mon, 30 Dec 2024 06:00:00 -0800

When Genes Collide: A Rare Diagnosis Reveals Complex Health Interactions with Dr. Philip Bretsky

For this episode, Dr. Bretsky shares a remarkable case study that unravels the complex relationship between genes and inflammation. When a patient's mysterious symptoms led to the rare diagnosis of VEXAS syndrome, it revealed an unexpected connection with cardiovascular health, demonstrating how different genetic factors can interact to amplify health risks.

Timestamps:

3:50 - Introduction to Lp(a) and its role in cardiovascular health
10:09 - Patient's initial presentation with testicular swelling
17:55 - Discussion of environmental factors and genetic mutations
23:28 - Understanding inflammation's role in cardiovascular risk
35:32 - Treatment decisions and stent placement
41:51 - Prevention strategies for inflammatory conditions
1:24:19 - Episode wrap-up and closing

Dr. Philip Bretsky's Contact Information:

Philip M. Bretsky MD PhD MPH FACP

1301 20th Street, Suite 230

Santa Monica, CA 90404

TEL: 310.828.4411

FAX: 310.828.2411

Facebook:@santamonicaprimarycare

Twitter / X: @santa_care

Instagram: @santa_monica_primary_care

Web: www.drbretsky.com & www.santamonicaprimarycare.com

My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Biography Health, where healthcare meets personalization. With their DNAbled™ Blueprint, Biography Health empowers you with a health plan based on your unique DNA, aiming to prevent disease and extend your life. Take control of your health journey with a plan as unique as you. Visit BiographyHealth.com and start your personalized healthcare journey today.

Other Resources Mentioned:

https://www.cnn.com/2023/01/24/health/vexas-syndrome-prevalence-study-wellness/index.html

https://www.amazon.com/Implementation-Personalized-Precision-Medicine-Prevention/dp/0323988083

Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg

Mon, 16 Dec 2024 06:00:00 -0800

Beauty Span and Health Span: Where Aesthetics Meets Longevity with Dr. Cory Goldberg

For this episode, we dive deep into the intersection of aesthetics and longevity with Dr. Cory Goldberg, a renowned plastic and craniofacial surgeon. Dr. Goldberg bridges the art of aesthetic medicine with the science of precision medicine, sharing groundbreaking insights on how oxidative stress affects both beauty and overall health, and discussing innovative approaches to extending both beauty span and health span.

Timestamps:

03:27:24 - Dr. Goldberg shares his background and journey from physiology to plastic surgery to precision medicine

23:31:24 - Deep discussion on senescent cells (zombie cells) and their impact on aging and health

35:13:13 - Exploration of the gut-skin-brain axis and microbiome connections

43:51:24 - Detailed explanation of reactive oxygen species (ROS) and their role in aging

57:46:07 - Discussion of GliSODin supplement and superoxide dismutase

1:18:52:13 - Dr. Goldberg's insights on diet, plant-based eating, and oxidative stress

1:27:27:15 - Overview of Dr. Goldberg's practice evolution and his vision for integrating longevity medicine with aesthetic medicine

Dr. Cory Goldberg

https://www.linkedin.com/in/corygoldbergmd/

https://www.corygoldbergmd.com/

https://www.instagram.com/drcorygoldbergmd/

Dr. Cory S. Goldberg BSc, MD, MASc, FRCS(C), FACS, MBA is a Plastic Surgeon with a fellowship in the Royal College of Physicians and Surgeons of Canada.

He is a diplomat of the American Board of Plastic Surgeons and is also a Fellow of the American College of Surgeons. He earned his MD degree from Queen’s University, Canada and completed his Plastic Surgery residency training at the University of Toronto, including a Master’s of Applied Science in Biomedical Engineering. He subsequently did sub-specialty fellowship training in Craniofacial Plastic Surgery at University of Southern California in Los Angeles, California.

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Sponsored by: Biography Health

From Flight Medic to Precision Medicine with Dr. Kat Schmolly

Mon, 02 Dec 2024 06:00:00 -0800

From Flight Medic to Precision Medicine with Dr. Kat Schmolly

In this episode, we're joined by Dr. Kat Schmolly. From her adventurous past as an Air Force Flight Medic to her current mission revolutionizing rare disease diagnosis, Dr. Schmolly shares her unique journey into precision medicine. We discuss why bringing personalized care to the frontlines of medicine is crucial, and explore how innovative technologies can transform the future of healthcare.

Timestamps:

2:58 - How Dr. Schmolly and Dr. Stanford connected over precision medicine

7:35 - Early observations of environmental impacts on military health

13:22 - The near-disaster flight mission that changed her path

26:43 - Why precision medicine stays in research vs clinical practice

43:58 - Starting ZebraMD to transform rare disease diagnosis

47:19 - Vision for bringing precision medicine to primary care

Dr. Kat Schmolly

linkedin.com/in/kat-schmolly

kschmolly@gmail.com

Dr. Kat Schmolly is a physician at Dartmouth Health, combining her clinical expertise with a passion for advancing personalized medicine. As the founder of ZebraMD, she focuses on innovative solutions for rare disease diagnostics through algorithm development and AI-powered clinical tools. A graduate of the David Geffen School of Medicine at UCLA, her work has included groundbreaking research in genetic and rare diseases.

Before pursuing medicine, Dr. Schmolly served as a flight medic in the United States Air Force, where she honed her skills in aerospace and critical care medicine. With experience ranging from cardiac R&D at Medtronic to porphyria research and precision medicine development, Dr. Schmolly continues to lead efforts that bridge cutting-edge technology with patient-centered care.

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Sponsored by: Biography Health

A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles

Mon, 18 Nov 2024 06:00:00 -0800

A Doctor's Mission: How Dr. Scoles Used Genetics to Transform Patient Care with Dr. Lyndell Scoles

In this episode, we explore pharmacogenomics, also known as genetic pharmaceutical profiling with Dr. Lyndell Scoles with MDVIP. He’s an early pioneer in using genetic testing to optimize medication choices. With over 30 years of experience in internal medicine, Dr. Scoles shares how genetic pharmaceutical profiling helps determine which medications will work best for each patient based on their unique genetic makeup. He presents compelling examples of how this approach has prevented hospitalizations and improved patient outcomes, including cases of heart failure prevention and depression treatment. We also discuss why this hasn't been widely adopted yet in medical practice, despite its potential to save billions in healthcare costs.

Note: As our first in-person recording, you may notice some echo and compressed audio quality in portions of the conversation - we appreciate your understanding as we continue to improve our in-person recording setup.

Timestamps:

00:02:49 - Dr. Scoles begins explaining his journey into pharmacogenomics and why he started implementing it in his practice

00:08:28 - Description of how genetic testing is done through cheek swabs and the three-category report system

00:25:30 - Powerful patient case study about adjusting antidepressant dosing based on genetic testing

00:29:54 - Discussion of Metoprolol case studies and the 8% of patients who can't metabolize it properly

00:45:34 - Moving patient story about treating a 13-year ulcer patient successfully using genetic insights

00:50:35 - Resources for physicians to learn more about pharmacogenomics

00:52:43 - Contact information and closing thoughts

Dr. Lyndell Scoles

5734246494

https://www.mdvip.com/doctors/lyndellscolesmd

drscoles@socket.net

Dr. Lyndell Scoles is a dedicated MDVIP-affiliated physician with over three decades of experience in internal medicine, renowned for his compassionate, patient-centered approach to healthcare. A strong advocate for personalized medicine, Dr. Scoles has integrated pharmacogenomics—also known as genetic pharmaceutical profiling—into his practice, completing this innovative testing for over 600 patients. This approach empowers him to tailor treatments to the unique genetic makeup of each individual, enhancing outcomes and minimizing adverse effects.

Dr. Scoles graduated Magna Cum Laude as valedictorian from the University of Missouri School of Medicine, where he earned his Doctorate of Medicine in 1990. He completed his residency in Internal Medicine at the same institution and holds certifications from the American Board of Internal Medicine and the International Society of Clinical Densitometry.

Throughout his career, Dr. Scoles has held numerous leadership positions, including Chief of Internal Medicine at Boone Hospital Center, and served as Medical Director for several care facilities, including nursing homes and Alzheimer's care units. His expertise and dedication to excellence have earned him numerous accolades, such as being named a Castle Connolly Top Doctor (2022–2024) and appearing in Inside Columbia’s Medical Guide as one of Columbia’s Favorite Doctors (2016).

Dr. Scoles is a member of esteemed professional societies, including the American Medical Association and the American Society of Internal Medicine. His practice is guided by the principle of treating the whole person—balancing physical, mental, and spiritual wellness—and building meaningful partnerships with his patients to achieve optimal health.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith

Mon, 04 Nov 2024 06:00:00 -0800

Ep. 15 - Beyond One-Size-Fits-All: The Science of Drug-Gene Interactions with Michelle Beckwith

This episode features Michelle "Shelly" Beckwith, a genetics pioneer since the 1990s who worked on the Human Genome Project. She breaks down how pharmacogenetic testing helps optimize medication choices by analyzing how patients' genetic variations affect drug metabolism. The discussion covers testing methods, insurance challenges, and the real-world implementation of pharmacogenetics in clinical practice. Through her work with MedTrait, Shelly explains how understanding a patient's genetic profile can lead to more precise medication dosing and better outcomes.

https://www.medtrait.net/

Timestamps:

00:02:34 - 00:04:18: Michelle Beckwith's Professional Background

00:04:19 - 00:08:34: Different Types of Genetic Testing

00:08:34 - 00:12:34: Technical Details of Testing Methods

00:12:34 - 00:27:24: Drug Metabolism & Clinical Applications

00:27:24 - 00:35:42: Population Genetics & Healthcare Access

00:35:42 - 00:45:52: Regulatory Environment & Future Challenges

00:45:52 - 01:12:32: Implementation & Practical Applications

01:12:32 - 01:14:10: Closing Remarks

—

Michelle Beckwith

shelly@ptclabs.com

Michelle Beckwith has been at the forefront of genetics since the 90s, contributing to projects like the Human Genome Project and co-founding a laboratory specializing in DNA Human Identity testing. Her work in clinical pharmacogenetics has evolved into the foundation of MedTrait, one of our key partners at Biography Health, providing genetic insights for personalized medicine.

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Sponsored by: Biography Health

Genotyping vs. Sequencing: What's the Difference? with Yelena Bykhovskaya, PhD

Mon, 21 Oct 2024 06:00:00 -0800

Genotyping vs. Sequencing: What's the Difference?

In this episode, Dr. William Stanford, Dr. Yelena Bykhovskaya and Taylor Cu discuss various genetic testing methods. The conversation compares genotyping, exome sequencing, and whole genome sequencing, with an emphasis on whole genome sequencing, which provides the most comprehensive genetic information.

Timestamps:

00:03:22 - Discussion begins on what popular genetic testing companies use (genotyping)

00:05:09 - Explanation of how genotyping chips (microarrays) work

00:17:24 - Clarification on the difference between genotyping and sequencing

00:20:31 - Introduction of the book analogy to explain different genetic testing methods

00:23:32 - Discussion on the pros and cons of whole genome sequencing vs. exome sequencing

00:25:48 - Conclusion on why whole genome sequencing is becoming the preferred method

Dr. William Stanford MD PHD FACP

drstanford@bhipm.com

Dr. Yelena Bykhovskaya

yelena@biographyhealth.com

Dr. Yelena Bykhovskaya is an accomplished scientist specializing in genetics and precision medicine. As the former Principal Scientist at Avellino Labs, she developed genetic tests for Mendelian and complex eye diseases using national and international collaborations. As the former Research Scientist at Cedars-Sinai, she made major advances in complex genetic eye diseases with groundbreaking genome-wide genetic analyses. Her earlier work in mitochondrial genetics led to major discoveries in maternally inherited deafness and other rare mitochondrial disorders. Holding a PhD in Biochemistry, Yelena has a publication record of widely cited forty-five articles in high-impact journals and delivered numerous oral and poster presentations at the national and international conferences, solidifying her leadership in genetic research.

Sponsored by: Biography Health

Bridging the Gap: Scientists and Physicians in Precision Medicine with Yelena Bykhovskaya, PhD

Mon, 07 Oct 2024 06:00:00 -0800

In this episode, Dr. Yelena Bykhovskaya, Chief Scientific Officer at Biography Health, shares her expertise in genetics. We explore the importance of both polygenic and monogenic risk scores in patient care. The conversation underscores the value of combining cutting-edge genetic analysis with traditional clinical factors in the evolving field of precision medicine, emphasizing the need for a comprehensive approach to patient care.

Resources Mentioned:

https://www.genomeweb.com/

https://www.insideprecisionmedicine.com/

Timestamps:

00:03:34 - LinkedIn sparks Bykhovskaya-Stanford collaboration

00:06:27 - Stanford highlights Bykhovskaya's genetic risk expertise

00:13:13 - Genetic risk vs. family history explained

00:18:18 - Human Genome Project revolutionizes genetic analysis

00:24:54 - Whole genome sequencing: Key to comprehensive risk assessment

00:28:49 - High polygenic scores rival monogenic variants in risk

00:33:33 - Early intervention: Combating genetic predispositions

00:38:09 - Integrated risk scores: Combining genetics and clinical factors

00:44:00 - Basic genetic knowledge empowers doctors

00:52:59 - Addressing European bias in genetic studies

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP

Mon, 23 Sep 2024 06:00:00 -0800

How Doctors are Using Genetic Data to Transform Patient Care with Philip Bretsky MD PhD MPH FACP

In this episode, we're joined by Dr. Philip Bretsky, a board-certified internist from Santa Monica with expertise in epidemiology and Alzheimer's research. Dr. Bretsky discusses how precision medicine is transforming healthcare by integrating genetics, biomarkers, and lifestyle factors. He explores the challenges and opportunities in implementing this approach, the evolving role of general practitioners, and how patients can advocate for personalized care. Dr. Bretsky also shares valuable resources for both health-conscious individuals and primary care providers interested in precision medicine. Join us for insights into the future of healthcare and strategies for better disease prevention and treatment.

Dr. Philip Bretsky's Contact Information:

Philip M. Bretsky MD PhD MPH FACP

1301 20th Street, Suite 230

Santa Monica, CA 90404

TEL: 310.828.4411

FAX: 310.828.2411

Facebook:@santamonicaprimarycare

Twitter / X: @santa_care

Instagram: @santa_monica_primary_care

Web: www.drbretsky.com & www.santamonicaprimarycare.com

My monthly newsletter: https://lp.constantcontactpages.com/su/JtF9zzR

Timestamps:

03:18 – Dr. Philip Bretsky’s career path and personalized care.

09:26 – Shifting from treating to preventing disease.

12:02 – Gene-environment interactions and polygenic risk scores.

19:15 – Managing complex health problems as a general practitioner.

29:06 – Reflections on the Human Genome Project’s impact.

36:29 – Case study: Preventing coronary events.

44:17 – Advice for patients on advocating for personalized

Resources Mentioned:

Books:

"Outlive" by Peter Attia
"The Age of Scientific Wellness" by Leroy Hood
"The Covenant of Water" by Abraham Verghese (fiction, but related to genetic conditions)

Podcasts/Newsletters:

Eric Topol's substack and Twitter feed
Peter Attia's podcast

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan

Mon, 09 Sep 2024 06:00:00 -0800

Redefining the Healthcare Model: Insights from 20-Year Executive Lucy Janoyan

In this episode, we're joined by special guest Lucy Janoyan, Chief Strategy Officer at Biography Health. With over two decades of healthcare executive experience, Lucy explores the transition from reactive to proactive healthcare. She discusses the challenges facing primary care providers, the role of genetic testing in personalized medicine, and how Biography Health is working to empower both patients and doctors. Lucy shares insights on continuous health monitoring, patient engagement, and the future of healthcare, offering valuable perspectives for healthcare professionals and health-conscious individuals alike.

Timestamps:

00:02:09 - Introduction of guest Lucy Janoyan, Chief Strategy Officer at Biography Health

00:03:28 - Lucy discusses her background and connection with Dr. Stanford

00:06:55 - Discussion of challenges in current healthcare system and move towards precision medicine

00:16:27 - Discussion of issues with current reactive "sick care" system

00:25:52 - Discussion of barriers for physicians in providing preventive care

00:32:28 - Overview of how Biography Health platform works for providers

00:48:56 - Details on Biography Health's features and benefits for providers and patients

00:56:53 - Discussion of ongoing patient monitoring and updates through the platform

01:18:51 - Closing thoughts and how listeners can learn more about Biography Health

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Gen Z Takes Action: The Preventive Health Shift

Mon, 26 Aug 2024 06:00:00 -0800

Gen Z Takes Action: The Preventive Health Shift

In this episode, we're joined by two younger guests for our Gen Z special featuring Eliana Stanford, Dr. Stanford's daughter, and Lexie Horizon, whose parents are fellow doctors and friends of Dr. Stanford, and who recently interned at Biography Health. This unique conversation explores why younger generations should care about and take action towards preventive healthcare.

Timestamps:

03:39:19 - Elena and Lexie introduce themselves and their backgrounds.

07:50:13 - Discussion on why younger generations are becoming interested in preventive healthcare.

11:37:23 - Dr. Stanford explains what whole genome sequencing is and how it differs from other genetic testing methods.

25:28:19 - Conversation about privacy concerns related to genetic data.

38:46:12 - Discussion on how precision medicine can benefit mental health treatment.

46:57:18 - Exploration of the challenges in making preventive care accessible and affordable.

54:35:01 - Dr. Stanford discusses the potential for precision medicine to improve healthcare in developing countries.

01:05:06 - Concluding remarks on the future of healthcare and the role of the younger generation in shaping it.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Taylor Can't Outrun His Genetics: Lipid Panel Reality Check

Mon, 12 Aug 2024 06:00:00 -0800

Taylor Can't Outrun His Genetics: Lipid Panel Reality Check

In this episode, Dr. Stanford and I uncover surprising truths from my advanced lipid panel. Despite my active lifestyle, the results reveal hidden risks for heart disease and diabetes. We explore how genetic factors and subtle imbalances can impact long-term health, and discuss targeted interventions that could make all the difference.

Timestamps:

00:02:39 - Overview of advanced lipid panel and family history

00:05:16 - Discussion of lipoprotein and genetic risk factors

00:08:31 - Analysis of lab results and inflammation markers

00:13:06 - Exploration of uric acid levels and gout risk

00:17:11 - Review of A1C levels and insulin resistance

00:23:33 - Realization of potential atherosclerosis at age 30

00:27:31 - Discussion on genetics vs. lifestyle choices

00:32:10 - Conversation about sugar alternatives and diet

00:38:17 - Projections of future health issues without intervention

00:49:14 - Recap of interventions and lifestyle changes

00:55:07 - Closing thoughts and importance of preventive care

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Lipids Explained: Insights for Heart Health

Mon, 29 Jul 2024 06:00:00 -0800

In this informative episode of the Precision Medicine Made Simple Podcast, we delve into the world of lipids with Dr. Stanford. Learn what lipids are and why they're crucial for your health, especially regarding heart disease prevention. We explore the differences between HDL and LDL cholesterol, discuss genetic factors influencing lipid levels, and explain why even vegetarians need to pay attention to their lipid profiles.

Dr. Stanford breaks down advanced lipid panels, explaining key markers like apolipoprotein B and lipoprotein(a). We address when to start checking your lipids and why family history is a powerful tool in assessing your risk. The episode also touches on exciting developments in lipid management, including potential new treatments for high lipoprotein(a) levels.

Timestamps:

03:12 - Explanation of what lipids are and their importance

06:02 - Discussion of atherosclerosis and heart disease risk

07:35 - Explanation of "good" vs "bad" cholesterol (HDL vs LDL)

11:28 - Discussion of vegetarian diets and cholesterol levels

13:16 - Introduction of familial hypercholesterolemia and lipoprotein(a)

16:21 - Lifestyle factors and genetic predisposition to high cholesterol

19:36 - Discussion of new medications and treatments in development

25:53 - Guidelines for lipid testing and personalized medicine approach

34:22 - Detailed explanation of advanced lipid panel markers

46:56 - Explanation of new drug development processes for lipid management

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

From Genes to Actions: Taylor's DNAbled Blueprint Experience

Mon, 15 Jul 2024 06:00:00 -0800

From Genes to Actions: Taylor's DNAbled Blueprint Experience

Today marks the beginning of an ongoing series where I'm pulling back the curtain on my personal journey through the DNAbled Blueprint process. You'll get an exclusive, firsthand look at:

My own intake form: Revealing insights from my personal and family health history
One of my genetic reports: Dr. Stanford examines my polygenic risk score, discussing my genetic predisposition to certain health conditions
My personalized DNAbled Blueprint consultation: Experience the moment I receive my tailored health recommendations and action plan

This intimate look at my health journey aims to demystify the process and inspire you to take charge of your own wellbeing.

Dr. Stanford has equipped me with specific action items, so we'll be recording numerous episodes discussing my results and the strategies I'm implementing. Join me as we explore the ongoing impact of precision medicine in real-time.

Plus, our sponsor Biography Health is offering early access users a special introductory rate for the DNAbled Blueprint. This includes app access, reports, and a personalized recommended health strategy.

If you're interested in participating, feel free to email me directly at taylor@biographyhealth.com.

Timestamps:

00:04:36 - Intake Form Walkthrough

00:38:26 - Allelica Report, Polygenic Risk Scores

00:53:25 - DNAbled Blueprint Consultation

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Cracked the Genetic Code! Methylation and the Future of Precision Medicine

Mon, 01 Jul 2024 06:00:00 -0800

Cracked the Genetic Code! Methylation and the Future of Precision Medicine

This is the second half of the two part series to Dr. Stanford’s presentation called, “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine.” For this episode, we dive into the science of methylation patterns and how we can use it to detect various cancers and their tissue origins enabling early intervention for better treatment outcomes and ultimately paving the way for tailored therapies. Similar to the last episode, there are supporting graphics and diagrams so we highly recommend watching this episode on our YouTube channel as this discussion does get pretty technical in various parts of the conversation.

Timestamps:

[00:04:22] Detecting cancer through DNA methylation patterns.

[00:08:56] DNA sequencing reveals gene expression patterns.

[00:12:15] Cancer turns off genes, DNA sequencing detects.

[00:16:01] Detect tumor DNA in bloodstream. Identify cancer signal.

[00:19:20] Methylation patterns in DNA detect cancer.

[00:22:55] Screening for cancer over fifty. Insurance doesn't cover yet.

[00:26:09] Precision medicine case study on heart health.

[00:29:25] Imaging center found life-saving genetic risk.

[00:32:24] Personalized medicine increases health span, reduces costs.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Precision Medicine 101: Crash Course

Mon, 17 Jun 2024 06:00:00 -0800

These next two episodes are a two part series to Dr. Stanford’s presentation called “Optimizing Healthspan and Longevity by Implementing Personalized Precision Medicine. Think of this episode like Precision Medicine 101. Dr. Stanford dives into a number of different topics including the evolution of personalized precision medicine and how its changing healthcare, the significance of knowing your risks by looking at genetics, family history, monogenic risks and polygenic risk scores, and pharmacogenomics which is tailoring drug treatments based on individual genetic variations. While this episode is available on audio platforms, we highly recommend watching this episode on YouTube as Dr. Stanford references numerous visuals and graphs.

Timestamps:

[00:06:05] Personalized precision medicine focuses on prevention and early detection. Patient-centered care needed for effectiveness. Regulatory bodies must adapt to rapid advancements.

[00:11:48] Genetic sequencing now faster, cheaper. Exciting advancements.

[00:18:06] Genetic variation leads to personalized medicine.

[00:22:53] Future of healthcare: personalized, predictive, proactive.

[00:28:20] Combining genetic and clinical factors.

[00:33:32] Assess risk using family history and polygenic risk scores.

[00:39:43] Risk stratification crucial for preventive care.

[00:45:03] Genetic testing can personalize drug treatment.

[00:49:39] Precision medicine improves drug reactions prediction.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

The Challenge with Cancer: It's Not That Simple

Mon, 03 Jun 2024 06:00:00 -0800

For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu discuss the topic of cancer. Dr. Stanford provides a comprehensive breakdown of cancer cells, stressing the need for genetic and molecular profiling to tailor treatments. They explore the factors that contribute to cancer development, including lifestyle choices and genetic mutations, and emphasize the importance of early detection through screenings and genetic analysis. They also dive into the exciting advancements in early cancer identification, as well as the role of the immune system in fighting cancer cells.

Timestamps:

[00:15:36] Preventative measures key to reducing cancer.

[00:30:57] Early detection key for cancer survival.

[00:47:08] Precision medicine uses genetic risk factors to predict future cancer risk and inform treatment decisions. Inflammation and oxidative stress play a role in cancer development.

[01:02:36] Cancer complexity and precision medicine summary.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

The Root of All Evil: Insulin Resistance

Mon, 20 May 2024 04:30:00 -0800

For this episode, Dr. Stanford, Alyssa Stanford, and Taylor Cu dive into the complexities of metabolic syndrome, how it can relate to several chronic diseases and discuss the impact of genetics, diet, and exercise on our overall health. We also touch on the importance of precision medicine and continuous glucose monitoring in managing conditions like diabetes and touch on some of the benefits of medications currently out there like Ozempic.

Timestamps:

[00:05:44] Metabolic syndrome increases chronic disease risk.

[00:10:26] Fatty liver disease is a modern problem.

[00:16:27] Processed foods worsen metabolic health, inflammation.

[00:22:40] Eating standing up may worsen insulin resistance.

[00:29:05] High insulin levels lead to diabetes.

[00:35:15] Dexcom for diabetics, Ozempic for symptoms.

[00:40:59] Medications show promise for various benefits.

[00:46:22] Metabolic syndrome is often overlooked.

[00:52:39] Improve health with precision medicine steps.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Alzheimer's: Could it Be Prevented?

Mon, 06 May 2024 06:00:00 -0800

In this episode, we’re joined by Dr. Stanford and Taylor Cu to explore neurodegenerative diseases such as Alzheimer’s and Parkinson's. It's a particularly personal discussion as Dr. Stanford shares his own genetic risk for Alzheimer’s, linked to the APOE4 gene. Dr. Stanford explains what neurodegenerative diseases are and dives into the specifics of Alzheimer's, including how genetics play a role in its risk. We wrap up the episode by looking at lifestyle changes that could make a significant impact in prevention.

Timestamps:

[00:04:50] Degenerative diseases share commonality in brain shrinkage. Alzheimer's is most common, starts early.

[00:09:24] APOE Epsilon four leads to abnormal function in cholesterol transport, amyloid plaques and tau proteins play a role in Alzheimer's disease progression.

[00:14:03] Alzheimer's disease is complex and mysterious.

[00:18:00] Lifestyle impacts neurodegenerative disease risk.

[00:22:37] Difference between Alzheimer's and general dementia.

[00:27:07] Inflammation bad for heart and brain.

[00:32:23] Genetic testing can predict future health.

[00:37:44] Prevent dementia with lifestyle changes.

[00:43:01] Improve brain health with exercise, socialization.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health

Heart Disease and More

Sat, 20 Apr 2024 06:00:00 -0800

Dr. Stanford, Alyssa Stanford, and Taylor Cu explore the fascinating world of heart disease and personalized health care. They dive into the complexities of heart disease, discussing the crucial role of genetics, family history, lifestyle, and biochemistry in assessing heart disease risk. Tune in to discover the power of early detection, personalized health plans, and integrative approaches to effectively address heart disease and more.

Timestamps:

[00:05:14] Arterial hardening and narrowing cause issues.

[00:09:11] Early onset heart disease linked to genetics.

[00:13:28] Genetic sequencing can predict heart attack.

[00:18:01] Improve lipid profile with medication, lifestyle.

[00:22:44] Genetic testing predicts future disease risk.

[00:27:35] Genetics and lifestyle impact heart disease.

[00:32:02] Gene editing for liver disease treatment.

[00:36:52] Liver cells have receptors for particles.

[00:42:23] Coronary disease and vascular health summary.

Dr. William Stanford MD PHD FACP

Sponsored by: Biography Health