Chronic pain affects nearly 1 in 4 American adults, but what if treating the pain is only addressing the symptom instead of what is driving it? CDC data show that 24.3% of U.S. adults experienced chronic pain in 2023.

In Episode 403, Dr. G explores the relationship between chronic inflammation, diet, and persistent pain. Research suggests that dietary patterns can influence inflammatory signaling and that whole-food dietary interventions may improve pain in some chronic-pain populations—although diet is not the sole cause of chronic pain and responses vary.

The episode also examines our reliance on medications to control pain. NSAIDs can reduce pain and inflammation, but they do not necessarily address the underlying driver of a patient's pain, and prolonged or inappropriate use can carry gastrointestinal, kidney, and cardiovascular risks.

Dr. G breaks down the inflammatory pathways behind pain—including PLA2, COX-1, COX-2, and 5-LOX—and explains how inflammatory mediators such as prostaglandins and leukotrienes contribute to the body's pain response.

The bigger question is not simply “What can I take for my pain?” but “Why is my body continuing to generate the signals that produce pain?”

Learn how food choices, inflammation, lifestyle, and conventional pain-management strategies intersect—and why identifying the underlying physiology may offer additional opportunities for managing chronic pain.

The Dr. G Show — Functional Lifestyle Medicine

Patients: GenomicWellnessGroup.com

Practitioners: MentoringFunctionalMedicine.com

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Is Type 2 diabetes really a lifelong, progressive disease—or can you change its course?

In this episode, Dr. G breaks down the physiology behind Type 2 diabetes, insulin resistance, and rising blood sugar—and explores how nutrition, movement, sleep, stress, and other lifestyle factors can improve metabolic health and, for some people, lead to Type 2 diabetes remission.

Learn how the body works, what disrupts normal glucose regulation, and what you can do to help restore healthier physiology.

Clients: GenomicWellnessGroup.com

Practitioners & Health Coaches: MentoringFunctionalMedicine.com

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Crohn's affects roughly 1 million Americans, causing chronic inflammation of the digestive tract and potentially serious complications.

In Episode 401, Dr. G takes a deeper look at Crohn’s disease—what it is, why rates have increased, how it’s diagnosed, and the conventional medications and treatments used to manage it. Then we explore the bigger question: What may be driving the abnormal immune response in the first place, and what role could diet and lifestyle play?

A patient-friendly discussion about Crohn’s disease through the lens of Functional Lifestyle Medicine.

GenomicWellnessGroup.com (To Schedule A Consult)

MentoringFunctionalMedicine.com (To Learn Functional Lifestyle Medicine)

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From the Ghetto to Dr. G: The Journey Behind the Mission

In this special 400th episode of The Dr. G Show, Dr. Patrick Garrett shares the story behind the man many know simply as "Dr. G."

Growing up in a rough neighborhood where violence was a daily reality, Dr. G faced challenges that could have easily altered the course of his life. After several close calls and witnessing firsthand the struggles that affect so many families, he made a decision to pursue education as a path forward.

That journey led him into an exclusive medical magnet program, followed by graduation from chiropractic college and subsequent attendance at medical school. Along the way, he completed more than 3,500 hours of clinical clerkships spanning surgery, pediatrics, psychiatry, family medicine, internal medicine, and geriatrics.

Driven by a passion for lifelong learning, Dr. G went on to earn five postdoctoral diplomates and advanced certifications while furthering his studies through the Harvard Medical School Lifestyle Medicine Program and numerous postgraduate educational institutions.

Recognizing that conventional approaches often failed to address the root causes of chronic disease, Dr. G developed what he calls Functional Lifestyle Medicine—a comprehensive model that combines lifestyle medicine, clinical nutrition, functional medicine, behavior change, and personalized health strategies.

Over the past two decades, he has traveled throughout the United States and internationally, lecturing to healthcare professionals and the public on chronic disease reversal, nutrition, inflammation, hormones, gut health, and human performance.

Since launching The Dr. G Show in 2016, he has produced more than 300 podcast episodes, interviewed experts from around the world, educated countless listeners, and built a global audience dedicated to healthier, happier, and more hormonally balanced lives.

Episode 400 is a reflection on the obstacles, lessons, successes, failures, and defining moments that shaped the journey from a kid growing up in the ghetto to becoming the educator, clinician, speaker, mentor, and podcast host known around the world as Dr. G.

Thank you for being part of the first 400 episodes. The mission continues.